Seroatlas · Human Serome Atlas

TIMM17B

Mitochondrial import inner membrane translocase subunit Tim17-B

Also known as: DXS9822, JM3, TI17B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60830
Gene: TIMM17B
Ensembl: ENSG00000126768
Chromosome: X
Canonical length: 172 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Microtubules,Mitochondria

OverviewNCBI Gene

This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>O60830|TIMM17B
     1  MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRLRG SANAVRIRAP
    61  QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSITSGALTG AVLAARSGPL AMVGSAMMGG
   121  ILLALIEGVG ILLTRYTAQQ FRNAPPFLED PSQLPPKDGT PAPGYPSYQQ YH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM17B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 96 nTPM
tongue: 92 nTPM
choroid plexus: 74 nTPM
heart muscle: 71 nTPM
parathyroid gland: 53 nTPM
kidney: 50 nTPM

Single-cell type

oocytes: 276 nCPM
hofbauer cells: 149 nCPM
esophageal apical cells: 149 nCPM
esophageal suprabasal cells: 125 nCPM
extravillous trophoblasts: 116 nCPM
migrating cytotrophoblasts: 113 nCPM

Immune cell

eosinophil: 206 nTPM
basophil: 200 nTPM
neutrophil: 162 nTPM
plasmacytoid DC: 146 nTPM
total PBMC: 142 nTPM
classical monocyte: 142 nTPM

Brain region

white matter: 37 nTPM
basal ganglia: 33 nTPM
thalamus: 31 nTPM
cerebellum: 31 nTPM
spinal cord: 31 nTPM
cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.09
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIMM17B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TIMM23

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM17B as an antibody target. Whether an autoantibody or antibody against TIMM17B could matter depends on whether native TIMM17B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM17B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM17B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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