Seroatlas · Human Serome Atlas

GKN2

Gastrokine-2

Also known as: blottin, BRICD1B, GDDR, GKN2_HUMAN, PRO813, TFIZ1, VLTI465

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XP6
Gene: GKN2
Ensembl: ENSG00000183607
Chromosome: 2
Canonical length: 184 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q86XP6|GKN2
     1  MKILVAFLVV LTIFGIQSHG YEVFNIISPS NNGGNVQETV TIDNEKNTAI INIHAGSCSS
    61  TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY IYEKQALDNM FSSKYTWVKY
   121  NPLESLIKDV DWFLLGSPIE KLCKHIPLYK GEVVENTHNV GAGGCAKAGL LGILGISICA
   181  DIHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GKN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 4,351 nTPM

Expression across tissuesHPA

Tissue

stomach: 4,351 nTPM
lung: 76 nTPM
spleen: 1.4 nTPM
duodenum: 0.9 nTPM
pancreas: 0.7 nTPM
placenta: 0.6 nTPM

Single-cell type

foveolar cells: 8,392 nCPM
alveolar cells type 2: 452 nCPM
alveolar cells type 1: 244 nCPM
transitional alveolar cells: 165 nCPM
oocytes: 55 nCPM
gastric chief cells: 50 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.64
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GKN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TFF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GKN2 as an antibody target. Whether an autoantibody or antibody against GKN2 could matter depends on whether native GKN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GKN2 is annotated as secreted, so native GKN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GKN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...