Seroatlas · Human Serome Atlas

TEDC1

Tubulin epsilon and delta complex protein 1

Also known as: C14orf80, TEDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SX3
Gene: TEDC1
Ensembl: ENSG00000185347
Chromosome: 14
Canonical length: 495 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q86SX3|TEDC1
     1  MGRRRQRVDP AAGARAGALP EAIAALSRSL PSGPSPEIFR RAKFDRPEAT SALWQLLFRV
    61  LSPLPAGNAL ASLALEVQAR LVKSALCSQG YPRLALAQLP EDGSQGSREL LLALSWLLAR
   121  GPVPEQMLAQ ARVPLGDEMT VCQCEALASP GPPAPHMEAE GPVDVRHVQW LMGKLRFRWR
   181  QLVSSQQEQC ALLSKIHLYT RGCHSDQSLS HLSVTEAEML RDPEGGQQVS GAGAAQNLDL
   241  AYPKCLHSFC TPGMGPRTFW NDLWLVCEQP GLLPGDWAAP LDPGGASACS LLSPFRALLR
   301  TLERENQRLE AVLAWRRSEL VFWRWMDTVL GTCAPEVPAA ASQPTFLPWV PERGGGELDL
   361  VVRELQALEE ELREAAERRR AAWEAKAGGC GRGPEWSAAR RASREAVEKE LGALQQCWER
   421  DGGPAQPHGP HRLVRREDGA AGDRDLRAAV VIRTLRSQEA CLEAVLRRLQ GQCRQELARL
   481  VGARPGLIWI PPPGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 14 nTPM
cerebral cortex: 13 nTPM
amygdala: 13 nTPM
hippocampal formation: 12 nTPM
spinal cord: 9 nTPM
midbrain: 8.9 nTPM

Single-cell type

extravillous trophoblasts: 32 nCPM
enteric transient amplifying cells: 29 nCPM
colonocytes: 27 nCPM
esophageal basal cells: 23 nCPM
monocyte progenitors: 23 nCPM
foveolar cells: 21 nCPM

Immune cell

plasmacytoid DC: 2.4 nTPM
memory CD8 T-cell: 1.4 nTPM
intermediate monocyte: 0.9 nTPM
memory CD4 T-cell: 0.8 nTPM
non-classical monocyte: 0.8 nTPM
myeloid DC: 0.7 nTPM

Brain region

medulla oblongata: 18 nTPM
cerebral cortex: 16 nTPM
basal ganglia: 15 nTPM
amygdala: 15 nTPM
white matter: 15 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.01
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of smoothened signaling pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tubulin epsilon and delta complex protein 1 domain
Tubulin epsilon and delta complex protein 1
Tubulin epsilon and delta complex protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEDC1 as an antibody target. Whether an autoantibody or antibody against TEDC1 could matter depends on whether native TEDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...