TEDC2
Tubulin epsilon and delta complex protein 2
Also known as: C16orf59, FLJ13909, TEDC2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7L2K0
- Gene
- TEDC2
- Ensembl
- ENSG00000162062
- Chromosome
- 16
- Canonical length
- 433 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cell Junctions
OverviewNCBI Gene
Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
433 residues, UniProt reviewed canonical sequence.
>Q7L2K0|TEDC2
1 MLPAGCSRRL VAELQGALDA CAQRQLQLEQ SLRVCRRLLH AWEPTGTRAL KPPPGPETNG
61 EDPLPACTPS PQDLKELEFL TQALEKAVRV RRGITKAGER DKAPSLKSRS IVTSSGTTAS
121 APPHSPGQAG GHASDTRPTK GLRQTTVPAK GHPERRLLSV GDGTRVGMGA RTPRPGAGLR
181 DQQMAPSAAP QAPEAFTLKE KGHLLRLPAA FRKAASQNSS LWAQLSSTQT SDSTDAAAAK
241 TQFLQNMQTA SGGPQPRLSA VEVEAEAGRL RKACSLLRLR MREELSAAPM DWMQEYRCLL
301 TLEGLQAMVG QCLHRLQELR AAVAEQPPRP CPVGRPPGAS PSCGGRAEPA WSPQLLVYSS
361 TQELQTLAAL KLRVAVLDQQ IHLEKVLMAE LLPLVSAAQP QGPPWLALCR AVHSLLCEGG
421 ARVLTILRDE PAVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 4.9 nTPM
Expression across tissuesHPA
Tissue
- testis: 4.9 nTPM
- bone marrow: 3.8 nTPM
- esophagus: 2.2 nTPM
- cerebral cortex: 2 nTPM
- lymph node: 2 nTPM
- thymus: 2 nTPM
Single-cell type
- differentiating spermatogonia: 50 nCPM
- oocytes: 32 nCPM
- undifferentiated spermatogonia: 21 nCPM
- extravillous trophoblasts: 15 nCPM
- cytotrophoblasts: 15 nCPM
- migrating cytotrophoblasts: 14 nCPM
Immune cell
- memory CD4 T-cell: 0.4 nTPM
- T-reg: 0.4 nTPM
- naive B-cell: 0.2 nTPM
- naive CD8 T-cell: 0.2 nTPM
- non-classical monocyte: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
Brain region
- cerebral cortex: 3.1 nTPM
- thalamus: 2.1 nTPM
- amygdala: 1.9 nTPM
- basal ganglia: 1.9 nTPM
- hippocampal formation: 1.8 nTPM
- pons: 1.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.37
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.29
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4693
- Domain of unknown function (DUF4693)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TEDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEDC2 as an antibody target. Whether an autoantibody or antibody against TEDC2 could matter depends on whether native TEDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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