Seroatlas · Human Serome Atlas

TECRL

Trans-2,3-enoyl-CoA reductase-like

Also known as: DKFZp313B2333, DKFZp313D0829, GPSN2L, SRD5A2L2, TECRL_HUMAN, TERL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYJ1
Gene: TECRL
Ensembl: ENSG00000205678
Chromosome: 4
Canonical length: 363 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. The protein belongs to the steroid 5-alpha reductase family. Mutations in this gene result in ventricular tachycardia, catecholaminergic polymorphic, 3. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q5HYJ1|TECRL
     1  MFKRHKSLAS ERKRALLSQR ATRFILKDDM RNFHFLSKLV LSAGPLRPTP AVKHSKTTHF
    61  EIEIFDAQTR KQICILDKVT QSSTIHDVKQ KFHKACPKWY PSRVGLQLEC GGPFLKDYIT
   121  IQSIAASSIV TLYATDLGQQ VSWTTVFLAE YTGPLLIYLL FYLRIPCIYD GKESARRLRH
   181  PVVHLACFCH CIHYIRYLLE TLFVHKVSAG HTPLKNLIMS CAFYWGFTSW IAYYINHPLY
   241  TPPSFGNRQI TVSAINFLIC EAGNHFINVM LSHPNHTGNN ACFPSPNYNP FTWMFFLVSC
   301  PNYTYEIGSW ISFTVMTQTL PVGIFTLLMS IQMSLWAQKK HKIYLRKFNS YIHRKSAMIP
   361  FIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TECRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 518 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 518 nTPM
skeletal muscle: 53 nTPM
tongue: 1.8 nTPM
blood vessel: 1.6 nTPM
prostate: 1.5 nTPM
bone marrow: 0.8 nTPM

Single-cell type

cardiomyocytes: 1,359 nCPM
myonuclei: 454 nCPM
thymic myoid cells: 34 nCPM
epicardial cells: 32 nCPM
adipocytes: 13 nCPM
other brain neurons: 8.7 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 4.5 nTPM
cerebellum: 3.9 nTPM
hypothalamus: 3.7 nTPM
thalamus: 3.6 nTPM
pons: 3.5 nTPM
medulla oblongata: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TECRL.

Disease | AllUniProt

Conditions TECRL is implicated in, by any mechanism.

Ventricular tachycardia, catecholaminergic polymorphic, 3 (CPVT3) MIM:614021

Disease | GeneticClinVar

25 pathogenic / likely-pathogenic of 379 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiovascular phenotype
Catecholaminergic polymorphic ventricular tachycardia 3
TECRL-related disorder
Catecholaminergic polymorphic ventricular tachycardia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

very-long-chain enoyl-CoA reductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TECRL as an antibody target. Whether an autoantibody or antibody against TECRL could matter depends on whether native TECRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TECRL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TECRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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