Seroatlas · Human Serome Atlas

TCEA1

Transcription elongation factor A protein 1

Also known as: GTF2S, SII, TCEA, TCEA1_HUMAN, TF2S, TFIIS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23193
Gene
TCEA1
Ensembl
ENSG00000187735
Chromosome
8
Canonical length
301 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of DNA-templated transcription. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>P23193|TCEA1
     1  MEDEVVRFAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV NAIRKQSTDE
    61  EVTSLAKSLI KSWKKLLDGP STEKDLDEKK KEPAITSQNS PEAREESTSS GNVSNRKDET
   121  NARDTYVSSF PRAPSTSDSV RLKCREMLAA ALRTGDDYIA IGADEEELGS QIEEAIYQEI
   181  RNTDMKYKNR VRSRISNLKD AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL
   241  TKEAIREHQM AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF
   301  C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
116 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 116 nTPM
  • tonsil: 105 nTPM
  • lymph node: 91 nTPM
  • liver: 84 nTPM
  • bone marrow: 77 nTPM
  • parathyroid gland: 75 nTPM

Single-cell type

  • erythrocyte progenitors: 284 nCPM
  • late spermatids: 238 nCPM
  • parietal cells: 225 nCPM
  • megakaryocytes: 223 nCPM
  • plasma cells: 204 nCPM
  • b-cells: 171 nCPM

Immune cell

  • memory B-cell: 215 nTPM
  • naive B-cell: 176 nTPM
  • T-reg: 153 nTPM
  • plasmacytoid DC: 118 nTPM
  • memory CD4 T-cell: 108 nTPM
  • gdT-cell: 105 nTPM

Brain region

  • white matter: 72 nTPM
  • spinal cord: 57 nTPM
  • medulla oblongata: 57 nTPM
  • basal ganglia: 56 nTPM
  • hypothalamus: 55 nTPM
  • cerebellum: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.9
gnomAD missense Z
1.38
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCEA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEA1 as an antibody target. Whether an autoantibody or antibody against TCEA1 could matter depends on whether native TCEA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCEA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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