Seroatlas · Human Serome Atlas

TANGO6

Transport and Golgi organization protein 6 homolog

Also known as: FLJ12688, KIAA1746, TMCO7, TNG6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0B7
Gene: TANGO6
Ensembl: ENSG00000103047
Chromosome: 16
Canonical length: 1094 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be involved in protein secretion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1094 residues, UniProt reviewed canonical sequence.

>Q9C0B7|TANGO6
     1  MAARQAVGSG AQETCGLDRI LEALKLLLSP GGSGSSSLQV TKHDVLLATL KSNLSALEDK
    61  FLKDPQWKNL KLLRDEIADK AEWPQNSVDV TWSFTSQTLL LLLCLKETMI RLAANFNPGK
   121  PNPRTPEVAP ALSPDALSIS QQKTVQFVLQ FVVTLGICPY LMPGVGVPLR YRTEFGAVVQ
   181  DVVCFDAAPD ATRRLYTSCK ALLNVAQHTS LGSLIFCHHF GDIAAGLCQL GFCPTKRKLL
   241  TPAEEVLTEE ERTLSRGALR DMLDQVYQPL AVRELLILQG GPPQSCTDVK TQMRCRAPAW
   301  LRRLCGQLLS ERLMRPNGVQ AVVRGILEGA GAGAAGGSDA EVTAADWKKC DLIAKILASC
   361  PQQSLSPENY YRDICPQVLD LFHFQDKLTA RQFQRVATTT FITLSRERPH LAAKYLLQPV
   421  LAPLHRCLNT AELSESDMVP GTILVTEEEL SRCIEDVFKV YVVGNEPLTV LMDSLLPVLG
   481  VLFLLYCFTK QSVSHIRSLC QEILLWILGK LERKKAIASL KGFAGLDKAV PSLHSLCQFR
   541  VATQGGIMIT IKEAISDEDE DEALYQKVSS EQGRVEHLGD LLSHCQECGL AGDFFIFCLK
   601  ELTHVASENE TELKTEPFSS KSLLELEQHQ TLLVEGQERK LLVLQLMAVL CERMSEQIFT
   661  NVTQVVDFVA ATLQRACASL AHQAESTVES QTLSMSMGLV AVMLGGAVQL KSSDFAVLKQ
   721  LLPLLEKVSN TYPDPVIQEL AVDLRITIST HGAFATEAVS MAAQSTLNRK DLEGKIEEQQ
   781  QTSHERPTDV AHSHLEQQQS HETAPQTGLQ SNAPIIPQGV NEPSTTTSQK SGSVTTEQLQ
   841  EVLLSAYDPQ IPTRAAALRT LSHWIEQREA KALEMQEKLL KIFLENLEHE DTFVYLSAIQ
   901  GVALLSDVYP EKILPDLLAQ YDSSKDKHTP ETRMKVGEVL MRIVRALGDM VSKYREPLIH
   961  TFLRGVRDPD GAHRASSLAN LGELCQRLDF LLGSVVHEVT ACLIAVAKTD GEVQVRRAAI
  1021  HVVVLLLRGL SQKATEVLSA VLKDLYHLLK HVVCLEPDDV AKLHAQLALE ELDDIMKNFL
  1081  FPPQKLEKKI MVLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TANGO6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

liver: 12 nTPM
skeletal muscle: 8.2 nTPM
choroid plexus: 6.3 nTPM
parathyroid gland: 5.6 nTPM
urinary bladder: 5.6 nTPM
blood vessel: 5.4 nTPM

Single-cell type

early spermatids: 221 nCPM
sertoli cells: 219 nCPM
choroid plexus epithelial cells: 171 nCPM
myonuclei: 163 nCPM
epididymal basal cells: 144 nCPM
foveolar cells: 129 nCPM

Immune cell

intermediate monocyte: 6.6 nTPM
non-classical monocyte: 6.2 nTPM
T-reg: 4.9 nTPM
myeloid DC: 4.8 nTPM
classical monocyte: 3.8 nTPM
MAIT T-cell: 3.5 nTPM

Brain region

choroid plexus: 15 nTPM
basal ganglia: 13 nTPM
white matter: 13 nTPM
hypothalamus: 12 nTPM
cerebellum: 12 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -1.47
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein secretion

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
RNA polymerase II assembly factor Rtp1, C-terminal domain 2
RNA polymerase II assembly factor Rtp1, C-terminal
TANGO6/Rtp1
TANGO6, N-terminal domain
TANGO6, HEAT repeat
Required for nuclear transport of RNA pol II C-terminus 2
Required for nuclear transport of RNA pol II C-terminus 1
Transport and Golgi organization protein 6 homolog, ARM-like repeat
TANGO6 N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TANGO6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TANGO6 as an antibody target. Whether an autoantibody or antibody against TANGO6 could matter depends on whether native TANGO6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TANGO6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TANGO6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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