Seroatlas · Human Serome Atlas

TAAR9

Trace amine-associated receptor 9

Also known as: TA3, TAAR9_HUMAN, TAR3, TRAR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RI9
Gene
TAAR9
Ensembl
ENSG00000237110
Chromosome
6
Canonical length
348 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Jul 2005]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q96RI9|TAAR9
     1  MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF
    61  KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL
   121  FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL
   181  VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS
   241  SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV
   301  YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAAR9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAAR9 as an antibody target. Whether an autoantibody or antibody against TAAR9 could matter depends on whether native TAAR9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAAR9 is annotated at the cell surface, where native TAAR9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAAR9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAAR9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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