TAAR8
Trace amine-associated receptor 8
Also known as: GPR102, TA5, TAAR8_HUMAN, TAR5, TRAR5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q969N4
- Gene
- TAAR8
- Ensembl
- ENSG00000146385
- Chromosome
- 6
- Canonical length
- 342 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
This gene is part of the trace amine receptor cluster on chromosome 6 and encodes an orphan G-protein coupled receptor. Upregulated expression of this gene in astroglial cells upon exposure to lipopolysaccharides suggests a function for the encoded protein in the brain. [provided by RefSeq, Jul 2016]
Canonical amino-acid sequenceUniProt
342 residues, UniProt reviewed canonical sequence.
>Q969N4|TAAR8
1 MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL LVMTSVLHFK
61 QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG AKFCTLHSCC DVAFCYSSVL
121 HLCFICIDRY IVVTDPLVYA TKFTVSVSGI CISVSWILPL TYSGAVFYTG VNDDGLEELV
181 SALNCVGGCQ IIVSQGWVLI DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS
241 SESYKIRVAK RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY
301 YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAAR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.52
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.57
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAAR8 as an antibody target. Whether an autoantibody or antibody against TAAR8 could matter depends on whether native TAAR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAAR8 is annotated at the cell surface, where native TAAR8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAAR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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