Seroatlas · Human Serome Atlas

TAAR6

Trace amine-associated receptor 6

Also known as: TA4, TAAR6_HUMAN, TRAR4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RI8
Gene: TAAR6
Ensembl: ENSG00000146383
Chromosome: 6
Canonical length: 345 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q96RI8|TAAR6
     1  MSSNSSLLVA VQLCYANVNG SCVKIPFSPG SRVILYIVFG FGAVLAVFGN LLVMISILHF
    61  KQLHSPTNFL VASLACADFL VGVTVMPFSM VRTVESCWYF GRSFCTFHTC CDVAFCYSSL
   121  FHLCFISIDR YIAVTDPLVY PTKFTVSVSG ICISVSWILP LMYSGAVFYT GVYDDGLEEL
   181  SDALNCIGGC QTVVNQNWVL TDFLSFFIPT FIMIILYGNI FLVARRQAKK IENTGSKTES
   241  SSESYKARVA RRERKAAKTL GVTVVAFMIS WLPYSIDSLI DAFMGFITPA CIYEICCWCA
   301  YYNSAMNPLI YALFYPWFRK AIKVIVTGQV LKNSSATMNL FSEHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAAR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

kidney: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.02
gnomAD missense Z: -1.15
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAAR6 as an antibody target. Whether an autoantibody or antibody against TAAR6 could matter depends on whether native TAAR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAAR6 is annotated at the cell surface, where native TAAR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAAR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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