TAAR1

Protein identityUniProt · HPA

UniProt accession

Q96RJ0

Gene

TAAR1

Ensembl

ENSG00000146399

Chromosome

6

Canonical length

339 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q96RJ0|TAAR1
     1  MMPFCHNIIN ISCVKNNWSN DVRASLYSLM VLIILTTLVG NLIVIVSISH FKQLHTPTNW
    61  LIHSMATVDF LLGCLVMPYS MVRSAEHCWY FGEVFCKIHT STDIMLSSAS IFHLSFISID
   121  RYYAVCDPLR YKAKMNILVI CVMIFISWSV PAVFAFGMIF LELNFKGAEE IYYKHVHCRG
   181  GCSVFFSKIS GVLTFMTSFY IPGSIMLCVY YRIYLIAKEQ ARLISDANQK LQIGLEMKNG
   241  ISQSKERKAV KTLGIVMGVF LICWCPFFIC TVMDPFLHYI IPPTLNDVLI WFGYLNSTFN
   301  PMVYAFFYPW FRKALKMMLF GKIFQKDSSR CKLFLELSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

4.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0

gnomAD missense Z

-0.69

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• G protein-coupled receptor signaling pathway
• phospholipase C-activating G protein-coupled receptor signaling pathway

Molecular functions

• G protein-coupled receptor activity
• trace-amine receptor activity

Cellular components

• endomembrane system
• endoplasmic reticulum membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Trace amine associated receptor family
• GPCR, rhodopsin-like, 7TM
• Trace Amine-Associated Receptor
• 7 transmembrane receptor (rhodopsin family)
• Trace amine associated receptor 1

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix