Seroatlas · Human Serome Atlas

SVOP

Synaptic vesicle 2-related protein

Also known as: DKFZp761H039, SVOP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4V2
Gene: SVOP
Ensembl: ENSG00000166111
Chromosome: 12
Canonical length: 548 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport and xenobiotic transport. Predicted to be located in synaptic vesicle. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>Q8N4V2|SVOP
     1  MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VHVGLEAVEL DDGAAVPKEF
    61  ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW
   121  QVALLTSVVF VGMMSSSTLW GNISDQYGRK TGLKISVLWT LYYGILSAFA PVYSWILVLR
   181  GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL
   241  LILSAVPLLL FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
   301  DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCGI SSRKKAVEAK
   361  CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK KTMALCFVIF SFCSLLLFIC
   421  VGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ
   481  VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRGLQES SHREWGQEMV GRGMHGAGVT
   541  RSNSGSQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SVOP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 25 nTPM
cerebellum: 20 nTPM
basal ganglia: 16 nTPM
hippocampal formation: 13 nTPM
hypothalamus: 13 nTPM
retina: 12 nTPM

Single-cell type

late spermatids: 185 nCPM
cone photoreceptor cells: 143 nCPM
gonadotrophs: 112 nCPM
rod photoreceptor cells: 108 nCPM
brain excitatory neurons: 107 nCPM
early spermatids: 96 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 46 nTPM
hippocampal formation: 40 nTPM
basal ganglia: 40 nTPM
hypothalamus: 37 nTPM
white matter: 29 nTPM
amygdala: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 2.46

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

xenobiotic transport

Molecular functions

transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Organic cation transport protein/SVOP
Major facilitator, sugar transporter-like
Major facilitator superfamily
Major facilitator superfamily domain
MFS transporter superfamily
Sugar (and other) transporter
Major Facilitator Superfamily
Synaptic vesicle 2-related protein-like, major facilitator superfamily domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SVOP as an antibody target. Whether an autoantibody or antibody against SVOP could matter depends on whether native SVOP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SVOP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SVOP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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