Seroatlas · Human Serome Atlas

SV2C

Synaptic vesicle glycoprotein 2C

Also known as: SV2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q496J9
Gene: SV2C
Ensembl: ENSG00000122012
Chromosome: 5
Canonical length: 727 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in several processes, including chemical synaptic transmission; neurotransmitter transport; and regulation of synaptic vesicle exocytosis. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be active in dopaminergic synapse and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

727 residues, UniProt reviewed canonical sequence.

>Q496J9|SV2C
     1  MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEEDDDDYYP
    61  AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN QAKDSIVSVG QPKGDEYKDR
   121  RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE
   181  TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG
   241  YGFFLFCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
   301  IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL
   361  KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT
   421  FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL SVWFPDVIKP LQSDEYALLT RNVERDKYAN
   481  FTINFTMENQ IHTGMEYDNG RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT
   541  VFDNTDFEPY KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
   601  ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE
   661  LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP ILLASTVLVC GGLVGLCLPD
   721  TRTQVLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SV2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 17 nTPM
midbrain: 12 nTPM
hypothalamus: 11 nTPM
retina: 3.9 nTPM
cerebral cortex: 2.1 nTPM
spinal cord: 1.3 nTPM

Single-cell type

somatotrophs: 420 nCPM
other brain neurons: 338 nCPM
brain inhibitory neurons: 287 nCPM
granulosa cells: 234 nCPM
retinal ganglion cells: 232 nCPM
neuroendocrine cells: 193 nCPM

Immune cell

basophil: 1.5 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 136 nTPM
pons: 97 nTPM
midbrain: 90 nTPM
cerebral cortex: 82 nTPM
basal ganglia: 72 nTPM
medulla oblongata: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SV2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SYT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SV2C as an antibody target. Whether an autoantibody or antibody against SV2C could matter depends on whether native SV2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SV2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SV2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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