Seroatlas · Human Serome Atlas

SURF2

Surfeit locus protein 2

Also known as: SURF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15527
Gene: SURF2
Ensembl: ENSG00000148291
Chromosome: 9
Canonical length: 256 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene shares a bidirectional promoter with surfeit 1 (SURF1; GeneID: 6834), which is located on the opposite strand. It encodes a conserved protein that is expressed in a variety of tissues. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q15527|SURF2
     1  MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP
    61  AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG
   121  VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD
   181  LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DEGRRETTVY RGLVQKRGKK QLGSLKKKFK
   241  SHHRKPKSFS SCKQPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SURF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 102 nTPM

Expression across tissuesHPA

Tissue

testis: 102 nTPM
amygdala: 34 nTPM
cerebral cortex: 32 nTPM
hippocampal formation: 30 nTPM
kidney: 29 nTPM
midbrain: 29 nTPM

Single-cell type

late spermatids: 1,268 nCPM
late primary spermatocytes: 471 nCPM
early spermatids: 419 nCPM
oocytes: 295 nCPM
undifferentiated spermatogonia: 118 nCPM
fallopian tube ciliated cells: 91 nCPM

Immune cell

T-reg: 42 nTPM
MAIT T-cell: 32 nTPM
memory CD4 T-cell: 30 nTPM
memory CD8 T-cell: 28 nTPM
naive CD4 T-cell: 28 nTPM
naive B-cell: 28 nTPM

Brain region

cerebral cortex: 10 nTPM
medulla oblongata: 8.9 nTPM
midbrain: 8.8 nTPM
thalamus: 8.7 nTPM
cerebellum: 8.6 nTPM
white matter: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: -1.07
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Surfeit locus protein 2
Surfeit locus protein 2 (SURF2)

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of SURF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SURF2 as an antibody target. Whether an autoantibody or antibody against SURF2 could matter depends on whether native SURF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SURF2 is annotated at the cell surface, where native SURF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SURF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...