UQCR10
Cytochrome b-c1 complex subunit 9
Also known as: HSPC051, QCR9, QCR9_HUMAN, UCCR7.2, UCRC
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UDW1
- Gene
- UQCR10
- Ensembl
- ENSG00000184076
- Chromosome
- 22
- Canonical length
- 63 aa
- Protein class
- Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
63 residues, UniProt reviewed canonical sequence.
>Q9UDW1|UQCR10
1 MAAATLTSKL YSLLFRRTST FALTIIVGVM FFERAFDQGA DAIYDHINEG KLWKHIKHKY
61 ENKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UQCR10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 477 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 477 nTPM
- tongue: 433 nTPM
- heart muscle: 410 nTPM
- choroid plexus: 201 nTPM
- basal ganglia: 187 nTPM
- amygdala: 186 nTPM
Single-cell type
- parietal cells: 2,809 nCPM
- hepatocytes: 1,502 nCPM
- late primary spermatocytes: 1,219 nCPM
- esophageal apical cells: 1,076 nCPM
- hofbauer cells: 999 nCPM
- esophageal suprabasal cells: 977 nCPM
Immune cell
- total PBMC: 1,162 nTPM
- eosinophil: 1,013 nTPM
- memory B-cell: 1,006 nTPM
- basophil: 985 nTPM
- T-reg: 893 nTPM
- plasmacytoid DC: 867 nTPM
Brain region
- cerebellum: 98 nTPM
- hypothalamus: 97 nTPM
- thalamus: 86 nTPM
- basal ganglia: 86 nTPM
- choroid plexus: 84 nTPM
- hippocampal formation: 84 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.76
- gnomAD pLI
- 0.14
- gnomAD missense Z
- -0.69
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cytochrome b-c1 complex subunit 9
- Cytochrome b-c1 complex subunit 9 superfamily
- Cytochrome b-c1 complex subunit 9
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of UQCR10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UQCR10 as an antibody target. Whether an autoantibody or antibody against UQCR10 could matter depends on whether native UQCR10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UQCR10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UQCR10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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