Seroatlas · Human Serome Atlas

ITM2C

Integral membrane protein 2C

Also known as: BRI3, BRICD2C, E25, hRPC.1050_D_4, ITM2C_HUMAN, ITM3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQX7
Gene: ITM2C
Ensembl: ENSG00000135916
Chromosome: 2
Canonical length: 267 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables amyloid-beta binding activity. Involved in negative regulation of neuron projection development and neuron differentiation. Located in several cellular components, including Golgi apparatus; lysosome; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q9NQX7|ITM2C
     1  MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGGSVGGVCY
    61  LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI
   121  YLDENYERIN VPVPQFGGGD PADIIHDFQR GLTAYHDISL DKCYVIELNT TIVLPPRNFW
   181  ELLMNVKRGT YLPQTYIIQE EMVVTEHVSD KEALGSFIYH LCNGKDTYRL RRRATRRRIN
   241  KRGAKNCNAI RHFENTFVVE TLICGVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITM2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 1,021 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 1,021 nTPM
cerebral cortex: 948 nTPM
amygdala: 836 nTPM
midbrain: 716 nTPM
hypothalamus: 681 nTPM
colon: 663 nTPM

Single-cell type

colonocytes: 2,243 nCPM
goblet cells: 864 nCPM
pdcs: 836 nCPM
enteric transient amplifying cells: 791 nCPM
plasma cells: 657 nCPM
enteric stem cells: 635 nCPM

Immune cell

plasmacytoid DC: 2,468 nTPM
eosinophil: 292 nTPM
memory B-cell: 186 nTPM
naive B-cell: 95 nTPM
basophil: 77 nTPM
myeloid DC: 69 nTPM

Brain region

thalamus: 1,335 nTPM
hypothalamus: 1,313 nTPM
midbrain: 1,077 nTPM
medulla oblongata: 1,013 nTPM
spinal cord: 976 nTPM
basal ganglia: 929 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.7
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITM2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITM2C as an antibody target. Whether an autoantibody or antibody against ITM2C could matter depends on whether native ITM2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITM2C is annotated at the cell surface, where native ITM2C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITM2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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