SPRR2A
Small proline-rich protein 2A
Also known as: SPR2A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P35326
- Gene
- SPRR2A
- Ensembl
- ENSG00000241794
- Chromosome
- 1
- Canonical length
- 72 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Enables lipid binding activity. Involved in antibacterial humoral response and defense response to Gram-positive bacterium. Located in cytoplasm. Is active in extracellular region and secretory granule. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
72 residues, UniProt reviewed canonical sequence.
>P35326|SPRR2A
1 MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS
61 PPCQSKYPPK SKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRR2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 5,424 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 5,424 nTPM
- cervix: 1,418 nTPM
- vagina: 1,297 nTPM
- salivary gland: 1,075 nTPM
- tonsil: 716 nTPM
- skin: 35 nTPM
Single-cell type
- esophageal apical cells: 42,736 nCPM
- esophageal suprabasal cells: 6,794 nCPM
- suprabasal keratinocytes: 3,283 nCPM
- esophageal basal cells: 783 nCPM
- ocular epithelial cells: 295 nCPM
- basal keratinocytes: 161 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.43
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antibacterial humoral response
- defense response to Gram-positive bacterium
- host-mediated modulation of intestinal microbiota composition
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SPRR2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRR2A as an antibody target. Whether an autoantibody or antibody against SPRR2A could matter depends on whether native SPRR2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRR2A is annotated as secreted, so native SPRR2A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Source-annotated serology context
The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.
- Involved in antibacterial humoral response and defense response to Gram-positive bacterium.
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