Seroatlas · Human Serome Atlas

SPNS3

Protein spinster homolog 3

Also known as: MGC29671, SLC63A3, SPNS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMD2
Gene: SPNS3
Ensembl: ENSG00000182557
Chromosome: 17
Canonical length: 512 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in lipid transport and transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q6ZMD2|SPNS3
     1  MAGGMSAECP EPGPGGLQGQ SPGPGRQCPP PITPTSWSLP PWRAYVAAAV LCYINLLNYM
    61  NWFIIAGVLL DIQEVFQISD NHAGLLQTVF VSCLLLSAPV FGYLGDRHSR KATMSFGILL
   121  WSGAGLSSSF ISPRYSWLFF LSRGIVGTGS ASYSTIAPTV LGDLFVRDQR TRVLAVFYIF
   181  IPVGSGLGYV LGSAVTMLTG NWRWALRVMP CLEAVALILL ILLVPDPPRG AAETQGEGAV
   241  GGFRSSWCED VRYLGKNWSF VWSTLGVTAM AFVTGALGFW APKFLLEARV VHGLQPPCFQ
   301  EPCSNPDSLI FGALTIMTGV IGVILGAEAA RRYKKVIPGA EPLICASSLL ATAPCLYLAL
   361  VLAPTTLLAS YVFLGLGELL LSCNWAVVAD ILLSVVVPRC RGTAEALQIT VGHILGDAGS
   421  PYLTGLISSV LRARRPDSYL QRFRSLQQSF LCCAFVIALG GGCFLLTALY LERDETRAWQ
   481  PVTGTPDSND VDSNDLERQG LLSGAGASTE EP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPNS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
thymus: 3.4 nTPM
lymph node: 1.9 nTPM
spleen: 1.9 nTPM
appendix: 1.3 nTPM
tonsil: 1.1 nTPM

Single-cell type

thymocytes: 134 nCPM
monocyte progenitors: 82 nCPM
pdcs: 73 nCPM
neutrophil progenitors: 58 nCPM
megakaryocytes: 50 nCPM
platelets: 42 nCPM

Immune cell

eosinophil: 355 nTPM
plasmacytoid DC: 128 nTPM
myeloid DC: 48 nTPM
classical monocyte: 6.5 nTPM
total PBMC: 6.2 nTPM
naive CD8 T-cell: 1.7 nTPM

Brain region

medulla oblongata: 2.2 nTPM
hypothalamus: 2 nTPM
white matter: 2 nTPM
spinal cord: 1.9 nTPM
pons: 1.7 nTPM
cerebellum: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPNS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CLCC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPNS3 as an antibody target. Whether an autoantibody or antibody against SPNS3 could matter depends on whether native SPNS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPNS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPNS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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