Seroatlas · Human Serome Atlas

CLCC1

Chloride channel CLIC-like protein 1

Also known as: CLCC1_HUMAN, MCLC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96S66
Gene
CLCC1
Ensembl
ENSG00000121940
Chromosome
1
Canonical length
551 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homomultimer

OverviewNCBI Gene

Enables chloride channel activity. Involved in endoplasmic reticulum calcium ion homeostasis. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Implicated in retinitis pigmentosa 32. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q96S66|CLCC1
     1  MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC
    61  ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD
   121  MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV
   181  DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH
   241  QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
   301  AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL
   361  RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR
   421  EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE
   481  GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP
   541  RGQDPVSSPC G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 24 nTPM
  • epididymis: 23 nTPM
  • liver: 21 nTPM
  • tongue: 21 nTPM
  • pancreas: 21 nTPM
  • salivary gland: 21 nTPM

Single-cell type

  • adrenal medulla cells: 21 nCPM
  • plasma cells: 20 nCPM
  • epididymal principal cells: 19 nCPM
  • cytotrophoblasts: 12 nCPM
  • megakaryocyte progenitors: 12 nCPM
  • breast lactating cells: 11 nCPM

Immune cell

  • non-classical monocyte: 13 nTPM
  • intermediate monocyte: 9.7 nTPM
  • MAIT T-cell: 7 nTPM
  • T-reg: 6.9 nTPM
  • plasmacytoid DC: 6.4 nTPM
  • eosinophil: 6.3 nTPM

Brain region

  • white matter: 34 nTPM
  • basal ganglia: 29 nTPM
  • medulla oblongata: 27 nTPM
  • spinal cord: 26 nTPM
  • hypothalamus: 25 nTPM
  • cerebellum: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLCC1.

Disease | AllUniProt

Conditions CLCC1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 337 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.01
gnomAD missense Z
1.1
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Chloride channel CLIC-like
  • Mid-1-related chloride channel (MCLC)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLCC1 as an antibody target. Whether an autoantibody or antibody against CLCC1 could matter depends on whether native CLCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLCC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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