Seroatlas · Human Serome Atlas

SNRNP48

U11/U12 small nuclear ribonucleoprotein 48 kDa protein

Also known as: C6orf151, dJ336K20B.1, dJ512B11.2, FLJ32234, SNR48_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IEG0
Gene: SNRNP48
Ensembl: ENSG00000168566
Chromosome: 6
Canonical length: 339 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in RNA splicing. Located in cytosol and nucleoplasm. Part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q6IEG0|SNRNP48
     1  MEGEPPPVEE RRRLQEELNE FVESGCRTLE EVTASLGWDL DSLDPGEEEA AEDEVVICPY
    61  DSNHHMPKSS LAKHMASCRL RKMGYTKEEE DEMYNPEFFY ENVKIPSITL NKDSQFQIIK
   121  QARTAVGKDS DCYNQRIYSS LPVEVPLNHK RFVCDLTQAD RLALYDFVVE ETKKKRSDSQ
   181  IIENDSDLFV DLAAKINQDN SRKSPKSYLE ILAEVRDYKR RRQSYRAKNV HITKKSYTEV
   241  IRDVINVHME ELSNHWQEEQ EKAEDDAEKN EERRSASVDS RQSGGSYLDA ECSRHRRDRS
   301  RSPHKRKRNK DKDKNCESRR RKERDGERHH SHKRRKQKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRNP48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 12 nTPM
bone marrow: 9.7 nTPM
skeletal muscle: 9.1 nTPM
ovary: 7.3 nTPM
heart muscle: 6.8 nTPM
liver: 6.8 nTPM

Single-cell type

endometrial luminal cells: 46 nCPM
thymic myoid cells: 42 nCPM
suprabasal keratinocytes: 42 nCPM
basal keratinocytes: 39 nCPM
neutrophils: 39 nCPM
tuft cells: 35 nCPM

Immune cell

neutrophil: 2.1 nTPM
MAIT T-cell: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM
naive B-cell: 1 nTPM
plasmacytoid DC: 1 nTPM
memory CD8 T-cell: 0.9 nTPM

Brain region

cerebellum: 14 nTPM
pons: 8.8 nTPM
medulla oblongata: 8.5 nTPM
white matter: 8.5 nTPM
cerebral cortex: 7.6 nTPM
thalamus: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 1.37
DepMap mean gene effect: -0.46
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRNP48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRNP48 as an antibody target. Whether an autoantibody or antibody against SNRNP48 could matter depends on whether native SNRNP48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRNP48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRNP48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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