Seroatlas · Human Serome Atlas

SLCO4C1

Solute carrier organic anion transporter family member 4C1

Also known as: OATP-H, OATP4C1, OATPX, SLC21A20, SO4C1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQN7
Gene: SLCO4C1
Ensembl: ENSG00000173930
Chromosome: 5
Canonical length: 724 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>Q6ZQN7|SLCO4C1
     1  MKSAKGIENL AFVPSSPDIL RRLSASPSQI EVSALSSDPQ RENSQPQELQ KPQEPQKSPE
    61  PSLPSAPPNV SEEKLRSLSL SEFEEGSYGW RNFHPQCLQR CNTPGGFLLH YCLLAVTQGI
   121  VVNGLVNISI STVEKRYEMK SSLTGLISSS YDISFCLLSL FVSFFGERGH KPRWLAFAAF
   181  MIGLGALVFS LPQFFSGEYK LGSLFEDTCV TTRNSTSCTS STSSLSNYLY VFILGQLLLG
   241  AGGTPLYTLG TAFLDDSVPT HKSSLYIGTG YAMSILGPAI GYVLGGQLLT IYIDVAMGES
   301  TDVTEDDPRW LGAWWIGFLL SWIFAWSLII PFSCFPKHLP GTAEIQAGKT SQAHQSNSNA
   361  DVKFGKSIKD FPAALKNLMK NAVFMCLVLS TSSEALITTG FATFLPKFIE NQFGLTSSFA
   421  ATLGGAVLIP GAALGQILGG FLVSKFRMTC KNTMKFALFT SGVALTLSFV FMYAKCENEP
   481  FAGVSESYNG TGELGNLIAP CNANCNCSRS YYYPVCGDGV QYFSPCFAGC SNPVAHRKPK
   541  VYYNCSCIER KTEITSTAET FGFEAKAGKC ETHCAKLPIF LCIFFIVIIF TFMAGTPITV
   601  SILRCVNHRQ RSLALGIQFM VLRLLGTIPG PIIFGFTIDS TCILWDINDC GIKGACWIYD
   661  NIKMAHMLVA ISVTCKVITM FFNGFAIFLY KPPPSATDVS FHKENAVVTN VLAEQDLNKI
   721  VKEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLCO4C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

kidney: 39 nTPM
bone marrow: 8.1 nTPM
lung: 7.4 nTPM
liver: 7.1 nTPM
seminal vesicle: 3.4 nTPM
gallbladder: 2.2 nTPM

Single-cell type

neutrophil progenitors: 286 nCPM
neutrophils: 198 nCPM
loop of henle epithelial cells: 107 nCPM
proximal tubule cells: 98 nCPM
alveolar cells type 2: 95 nCPM
monocyte progenitors: 65 nCPM

Immune cell

neutrophil: 9.8 nTPM
basophil: 9.5 nTPM
eosinophil: 7.3 nTPM
gdT-cell: 3.8 nTPM
NK-cell: 2.6 nTPM
memory CD8 T-cell: 2.1 nTPM

Brain region

cerebral cortex: 2.7 nTPM
hypothalamus: 2.7 nTPM
white matter: 2.5 nTPM
basal ganglia: 2.4 nTPM
pons: 2.1 nTPM
hippocampal formation: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLCO4C1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CANX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLCO4C1 as an antibody target. Whether an autoantibody or antibody against SLCO4C1 could matter depends on whether native SLCO4C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLCO4C1 is annotated at the cell surface, where native SLCO4C1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLCO4C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...