Seroatlas · Human Serome Atlas

SLC39A7

Zinc transporter SLC39A7

Also known as: D6S2244E, H2-KE4, HKE4, KE4, RING5, S39A7_HUMAN, ZIP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92504
Gene
SLC39A7
Ensembl
ENSG00000112473
Chromosome
6
Canonical length
469 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q92504|SLC39A7
     1  MARGLGAPHW VAVGLLTWAT LGLLVAGLGG HDDLHDDLQE DFHGHSHRHS HEDFHHGHSH
    61  AHGHGHTHES IWHGHTHDHD HGHSHEDLHH GHSHGYSHES LYHRGHGHDH EHSHGGYGES
   121  GAPGIKQDLD AVTLWAYALG ATVLISAAPF FVLFLIPVES NSPRHRSLLQ ILLSFASGGL
   181  LGDAFLHLIP HALEPHSHHT LEQPGHGHSH SGQGPILSVG LWVLSGIVAF LVVEKFVRHV
   241  KGGHGHSHGH GHAHSHTRGS HGHGRQERST KEKQSSEEEE KETRGVQKRR GGSTVPKDGP
   301  VRPQNAEEEK RGLDLRVSGY LNLAADLAHN FTDGLAIGAS FRGGRGLGIL TTMTVLLHEV
   361  PHEVGDFAIL VQSGCSKKQA MRLQLLTAVG ALAGTACALL TEGGAVGSEI AGGAGPGWVL
   421  PFTAGGFIYV ATVSVLPELL REASPLQSLL EVLGLLGGVI MMVLIAHLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 92 nTPM
  • salivary gland: 85 nTPM
  • blood vessel: 69 nTPM
  • stomach: 67 nTPM
  • liver: 67 nTPM
  • adrenal gland: 67 nTPM

Single-cell type

  • prostatic glandular cells: 34 nCPM
  • plasma cells: 34 nCPM
  • salivary acinar cells: 27 nCPM
  • conjunctival goblet cells: 24 nCPM
  • breast lactating cells: 24 nCPM
  • tuft cells: 23 nCPM

Immune cell

  • MAIT T-cell: 4.4 nTPM
  • gdT-cell: 3.3 nTPM
  • basophil: 2.2 nTPM
  • NK-cell: 2.1 nTPM
  • eosinophil: 2 nTPM
  • memory CD4 T-cell: 2 nTPM

Brain region

  • choroid plexus: 10 nTPM
  • thalamus: 5.3 nTPM
  • medulla oblongata: 5.2 nTPM
  • pons: 4.9 nTPM
  • white matter: 4.6 nTPM
  • hypothalamus: 4.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A7.

Disease | AllUniProt

Conditions SLC39A7 is implicated in, by any mechanism.

  • Agammaglobulinemia 9, autosomal recessive (AGM9) MIM:619693

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 260 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Agammaglobulinemia 9, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.08
gnomAD missense Z
1.53
DepMap mean gene effect
-0.99
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC39A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A7 as an antibody target. Whether an autoantibody or antibody against SLC39A7 could matter depends on whether native SLC39A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC39A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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