Seroatlas · Human Serome Atlas

FAM174A

Membrane protein FAM174A

Also known as: F174A_HUMAN, NS5ATP6, TMEM157, UNQ1912

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBP5
Gene: FAM174A
Ensembl: ENSG00000174132
Chromosome: 5
Canonical length: 190 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q8TBP5|FAM174A
     1  MKASQCCCCL SHLLASVLLL LLLPELSGPL AVLLQAAEAA PGLGPPDPRP RTLPPLPPGP
    61  TPAQQPGRGL AEAAGPRGSE GGNGSNPVAG LETDDHGGKA GEGSVGGGLA VSPNPGDKPM
   121  TQRALTVLMV VSGAVLVYFV VRTVRMRRRN RKTRRYGVLD TNIENMELTP LEQDDEDDDN
   181  TLFDANHPRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM174A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 40 nTPM
fallopian tube: 33 nTPM
hypothalamus: 30 nTPM
skin: 30 nTPM
parathyroid gland: 28 nTPM
cerebral cortex: 27 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 402 nCPM
fallopian tube ciliated cells: 320 nCPM
respiratory ciliated cells: 306 nCPM
breast lactating cells: 245 nCPM
endometrial ciliated cells: 231 nCPM
esophageal apical cells: 177 nCPM

Immune cell

neutrophil: 56 nTPM
basophil: 8 nTPM
eosinophil: 7.1 nTPM
non-classical monocyte: 5.7 nTPM
intermediate monocyte: 5.5 nTPM
NK-cell: 5.5 nTPM

Brain region

choroid plexus: 40 nTPM
hypothalamus: 30 nTPM
pons: 22 nTPM
cerebral cortex: 22 nTPM
white matter: 21 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM174A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC39A7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM174A as an antibody target. Whether an autoantibody or antibody against FAM174A could matter depends on whether native FAM174A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM174A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM174A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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