Seroatlas · Human Serome Atlas

SLC39A1

Zinc transporter ZIP1

Also known as: S39A1_HUMAN, ZIP1, ZIRTL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NY26
Gene: SLC39A1
Ensembl: ENSG00000143570
Chromosome: 1
Canonical length: 324 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q9NY26|SLC39A1
     1  MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE
    61  GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL AALHVTLQFP LQEFILAMGF
   121  FLVLVMEQIT LAYKEQSGPS PLEETRALLG TVNGGPQHWH DGPGVPQASG APATPSALRA
   181  CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA
   241  GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE
   301  QRILKVILLL AGFALLTGLL FIQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

placenta: 89 nTPM
lung: 86 nTPM
blood vessel: 77 nTPM
liver: 74 nTPM
adrenal gland: 71 nTPM
kidney: 70 nTPM

Single-cell type

cytotrophoblasts: 65 nCPM
migrating cytotrophoblasts: 60 nCPM
extravillous trophoblasts: 57 nCPM
epididymal basal cells: 38 nCPM
paneth cells: 35 nCPM
epididymal efferent duct absorptive cells: 31 nCPM

Immune cell

non-classical monocyte: 96 nTPM
intermediate monocyte: 79 nTPM
classical monocyte: 68 nTPM
neutrophil: 68 nTPM
total PBMC: 58 nTPM
myeloid DC: 56 nTPM

Brain region

medulla oblongata: 55 nTPM
thalamus: 42 nTPM
choroid plexus: 40 nTPM
spinal cord: 40 nTPM
midbrain: 37 nTPM
white matter: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0.13
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC39A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HTR2C

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A1 as an antibody target. Whether an autoantibody or antibody against SLC39A1 could matter depends on whether native SLC39A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A1 is annotated at the cell surface, where native SLC39A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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