Seroatlas · Human Serome Atlas

SLC35A3

UDP-N-acetylglucosamine transporter

Also known as: S35A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2D2
Gene
SLC35A3
Ensembl
ENSG00000117620
Chromosome
1
Canonical length
325 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q9Y2D2|SLC35A3
     1  MFANLKYVSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK
    61  DSKCSLRALN RVLHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK
   121  ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QLDSKELSAG SQFVGLMAVL
   181  TACFSSGFAG VYFEKILKET KQSVWIRNIQ LGFFGSIFGL MGVYIYDGEL VSKNGFFQGY
   241  NRLTWIVVVL QALGGLVIAA VIKYADNILK GFATSLSIIL STLISYFWLQ DFVPTSVFFL
   301  GAILVITATF LYGYDPKPAG NPTKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 51 nTPM
  • colon: 50 nTPM
  • duodenum: 47 nTPM
  • small intestine: 39 nTPM
  • liver: 35 nTPM
  • stomach: 32 nTPM

Single-cell type

  • cardiomyocytes: 20 nCPM
  • megakaryocytes: 12 nCPM
  • adipocytes: 5.2 nCPM
  • respiratory deuterosomal cells: 3.1 nCPM
  • colonocytes: 3 nCPM
  • neuroendocrine cells: 3 nCPM

Immune cell

  • plasmacytoid DC: 5 nTPM
  • NK-cell: 4.3 nTPM
  • basophil: 4.2 nTPM
  • T-reg: 2.8 nTPM
  • naive CD4 T-cell: 2.6 nTPM
  • MAIT T-cell: 2.5 nTPM

Brain region

  • choroid plexus: 24 nTPM
  • cerebellum: 16 nTPM
  • white matter: 15 nTPM
  • pons: 13 nTPM
  • basal ganglia: 13 nTPM
  • thalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC35A3.

Disease | AllUniProt

Conditions SLC35A3 is implicated in, by any mechanism.

  • Arthrogryposis, impaired intellectual development, and seizures (AMRS) MIM:615553

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 362 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
1.42
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35A3 as an antibody target. Whether an autoantibody or antibody against SLC35A3 could matter depends on whether native SLC35A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC35A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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