Seroatlas · Human Serome Atlas

SLC22A8

Organic anion transporter 3

Also known as: OAT3, S22A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TCC7
Gene
SLC22A8
Ensembl
ENSG00000149452
Chromosome
11
Canonical length
542 aa
Protein class
FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q8TCC7|SLC22A8
     1  MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW
    61  VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV YNSTKDSIVT EWDLVCNSNK
   121  LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR
   181  FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL
   241  TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN
   301  LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI
   361  IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG
   421  CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI
   481  TALLGGSAAL FLPETLNQPL PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG
   541  SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
313 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 313 nTPM
  • choroid plexus: 266 nTPM
  • cerebral cortex: 1.5 nTPM
  • cerebellum: 0.5 nTPM
  • retina: 0.5 nTPM
  • pituitary gland: 0.3 nTPM

Single-cell type

  • retinal pigment epithelial cells: 465 nCPM
  • proximal tubule cells: 148 nCPM
  • choroid plexus epithelial cells: 148 nCPM
  • retinal bipolar cells: 16 nCPM
  • mast cells: 5 nCPM
  • renal connecting tubule cells: 4.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 243 nTPM
  • hippocampal formation: 7.7 nTPM
  • cerebellum: 3.5 nTPM
  • thalamus: 2.9 nTPM
  • cerebral cortex: 0.9 nTPM
  • midbrain: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.97
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A8 as an antibody target. Whether an autoantibody or antibody against SLC22A8 could matter depends on whether native SLC22A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A8 is annotated at the cell surface, where native SLC22A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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