SLC22A4

Protein identityUniProt · HPA

UniProt accession

Q9H015

Gene

SLC22A4

Ensembl

ENSG00000197208

Chromosome

5

Canonical length

551 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q9H015|SLC22A4
     1  MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC RVPDAANLSS
    61  AWRNNSVPLR LRDGREVPHS CSRYRLATIA NFSALGLEPG RDVDLGQLEQ ESCLDGWEFS
   121  QDVYLSTVVT EWNLVCEDNW KVPLTTSLFF VGVLLGSFVS GQLSDRFGRK NVLFATMAVQ
   181  TGFSFLQIFS ISWEMFTVLF VIVGMGQISN YVVAFILGTE ILGKSVRIIF STLGVCTFFA
   241  VGYMLLPLFA YFIRDWRMLL LALTVPGVLC VPLWWFIPES PRWLISQRRF REAEDIIQKA
   301  AKMNNIAVPA VIFDSVEELN PLKQQKAFIL DLFRTRNIAI MTIMSLLLWM LTSVGYFALS
   361  LDAPNLHGDA YLNCFLSALI EIPAYITAWL LLRTLPRRYI IAAVLFWGGG VLLFIQLVPV
   421  DYYFLSIGLV MLGKFGITSA FSMLYVFTAE LYPTLVRNMA VGVTSTASRV GSIIAPYFVY
   481  LGAYNRMLPY IVMGSLTVLI GILTLFFPES LGMTLPETLE QMQKVKWFRS GKKTRDSMET
   541  EENPKVLITA F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

12

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

20 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC22A4.

Disease | AllUniProt

Conditions SLC22A4 is implicated in, by any mechanism.

• Rheumatoid arthritis (RA) MIM:180300

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.98

gnomAD pLI

0

gnomAD missense Z

0.85

DepMap mean gene effect

-0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acetylcholine uptake
• amino acid import across plasma membrane
• carnitine metabolic process
• carnitine transport
• lactation
• liver regeneration
• quaternary ammonium group transport
• response to exogenous dsRNA
• response to lipopolysaccharide
• response to vitamin D
• sodium ion transport
• triglyceride metabolic process
• xenobiotic transport
• sulfur amino acid transport

Molecular functions

• acetylcholine transmembrane transporter activity
• amino acid transmembrane transporter activity
• amino-acid betaine transmembrane transporter activity
• ATP binding
• carnitine transmembrane transporter activity
• PDZ domain binding
• quaternary ammonium group transmembrane transporter activity
• symporter activity
• secondary active organic cation transmembrane transporter activity

Cellular components

• apical plasma membrane
• basal plasma membrane
• mitochondrial membrane
• mitochondrion
• neuronal cell body
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Organic cation transport protein/SVOP
• Major facilitator, sugar transporter-like
• Sugar transporter, conserved site
• Major facilitator superfamily domain
• MFS transporter superfamily
• Solute carrier family 22 members 4/5
• Sugar (and other) transporter

KeywordsUniProt

• ATP-binding
• Cell membrane
• Glycoprotein
• Ion transport
• Membrane
• Mitochondrion
• Nucleotide-binding
• Sodium
• Sodium transport
• Symport
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of SLC22A4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PDZK1