Seroatlas · Human Serome Atlas

SLC22A3

Solute carrier family 22 member 3

Also known as: EMT, OCT3, S22A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75751
Gene
SLC22A3
Ensembl
ENSG00000146477
Chromosome
6
Canonical length
556 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>O75751|SLC22A3
     1  MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA
    61  ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR
   121  SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG
   181  RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR
   241  IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK
   301  GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT
   361  SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA
   421  CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG
   481  GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS
   541  CKCGRNKKTP VSRSHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 77 nTPM
  • skeletal muscle: 64 nTPM
  • seminal vesicle: 50 nTPM
  • salivary gland: 49 nTPM
  • placenta: 42 nTPM
  • prostate: 41 nTPM

Single-cell type

  • prostatic glandular cells: 647 nCPM
  • salivary acinar cells: 271 nCPM
  • alveolar cells type 2: 251 nCPM
  • transitional alveolar cells: 244 nCPM
  • leydig cells: 209 nCPM
  • myonuclei: 193 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 12 nTPM
  • pons: 8.2 nTPM
  • thalamus: 7.5 nTPM
  • midbrain: 7 nTPM
  • hypothalamus: 6 nTPM
  • spinal cord: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A3 as an antibody target. Whether an autoantibody or antibody against SLC22A3 could matter depends on whether native SLC22A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A3 is annotated at the cell surface, where native SLC22A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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