Seroatlas · Human Serome Atlas

SLC15A2

Solute carrier family 15 member 2

Also known as: PEPT2, S15A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16348
Gene
SLC15A2
Ensembl
ENSG00000163406
Chromosome
3
Canonical length
729 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q16348|SLC15A2
     1  MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY
    61  YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV
   121  YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER
   181  TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK
   241  IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT
   301  RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD
   361  FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN
   421  LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS
   481  VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG
   541  EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED
   601  IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV
   661  LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI
   721  KLETKKTKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC15A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 48 nTPM
  • prostate: 37 nTPM
  • epididymis: 37 nTPM
  • salivary gland: 23 nTPM
  • seminal vesicle: 21 nTPM
  • cerebral cortex: 20 nTPM

Single-cell type

  • astrocytes: 206 nCPM
  • respiratory secretory cells: 163 nCPM
  • microglia: 160 nCPM
  • salivary duct cells: 158 nCPM
  • prostatic glandular cells: 133 nCPM
  • alveolar cells type 1: 132 nCPM

Immune cell

  • memory B-cell: 1.3 nTPM
  • naive B-cell: 1.3 nTPM
  • non-classical monocyte: 1.1 nTPM
  • basophil: 0.9 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • classical monocyte: 0.4 nTPM

Brain region

  • thalamus: 41 nTPM
  • basal ganglia: 36 nTPM
  • cerebral cortex: 35 nTPM
  • midbrain: 34 nTPM
  • amygdala: 34 nTPM
  • medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC15A2 as an antibody target. Whether an autoantibody or antibody against SLC15A2 could matter depends on whether native SLC15A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC15A2 is annotated at the cell surface, where native SLC15A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC15A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC15A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...