Seroatlas · Human Serome Atlas

SLC14A1

Urea transporter 1

Also known as: HsT1341, JK, RACH1, RACH2, UT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13336
Gene
SLC14A1
Ensembl
ENSG00000141469
Chromosome
18
Canonical length
389 aa
Protein class
Blood group antigen proteins, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q13336|SLC14A1
     1  MEDSPTMVRV DSPTMVRGEN QVSPCQGRRC FPKALGYVTG DMKELANQLK DKPVVLQFID
    61  WILRGISQVV FVNNPVSGIL ILVGLLVQNP WWALTGWLGT VVSTLMALLL SQDRSLIASG
   121  LYGYNATLVG VLMAVFSDKG DYFWWLLLPV CAMSMTCPIF SSALNSMLSK WDLPVFTLPF
   181  NMALSMYLSA TGHYNPFFPA KLVIPITTAP NISWSDLSAL ELLKSIPVGV GQIYGCDNPW
   241  TGGIFLGAIL LSSPLMCLHA AIGSLLGIAA GLSLSAPFED IYFGLWGFNS SLACIAMGGM
   301  FMALTWQTHL LALGCALFTA YLGVGMANFM AEVGLPACTW PFCLATLLFL IMTTKNSNIY
   361  KMPLSKVTYP EENRIFYLQA KKRMVESPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC14A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 85 nTPM
  • prostate: 73 nTPM
  • midbrain: 52 nTPM
  • kidney: 46 nTPM
  • basal ganglia: 46 nTPM
  • blood vessel: 46 nTPM

Single-cell type

  • astrocytes: 478 nCPM
  • prostatic hillock cells: 325 nCPM
  • urothelial cells: 313 nCPM
  • medullary thymic epithelial cells: 286 nCPM
  • papillary tip epithelial cells: 168 nCPM
  • basal prostatic cells: 150 nCPM

Immune cell

  • T-reg: 4.1 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • eosinophil: 1.2 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • memory CD8 T-cell: 0.9 nTPM
  • NK-cell: 0.9 nTPM

Brain region

  • thalamus: 256 nTPM
  • midbrain: 254 nTPM
  • medulla oblongata: 211 nTPM
  • cerebellum: 207 nTPM
  • white matter: 189 nTPM
  • spinal cord: 183 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC14A1.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 73 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.5
gnomAD pLI
0
gnomAD missense Z
-0.01
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC14A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC14A1 as an antibody target. Whether an autoantibody or antibody against SLC14A1 could matter depends on whether native SLC14A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC14A1 is annotated at the cell surface, where native SLC14A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC14A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC14A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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