Seroatlas · Human Serome Atlas

FLOT2

Flotillin-2

Also known as: ECS-1, ECS1, ESA, ESA1, FLOT2_HUMAN, M17S1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14254
Gene: FLOT2
Ensembl: ENSG00000132589
Chromosome: 17
Canonical length: 428 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q14254|FLOT2
     1  MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM TLQPRCEDVE
    61  TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK NVVLQTLEGH LRSILGTLTV
   121  EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD
   181  IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA
   241  YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI
   301  AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK YGDAAKMALV
   361  LEALPQIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA ELPASVHALT GVDLSKIPLI
   421  KKATGVQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLOT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

spleen: 91 nTPM
bone marrow: 89 nTPM
urinary bladder: 72 nTPM
liver: 70 nTPM
blood vessel: 67 nTPM
lymph node: 61 nTPM

Single-cell type

neutrophils: 1,028 nCPM
late spermatids: 354 nCPM
neutrophil progenitors: 335 nCPM
thymic myoid cells: 144 nCPM
cytotrophoblasts: 142 nCPM
monocyte progenitors: 139 nCPM

Immune cell

neutrophil: 416 nTPM
eosinophil: 213 nTPM
basophil: 171 nTPM
myeloid DC: 144 nTPM
total PBMC: 143 nTPM
naive B-cell: 118 nTPM

Brain region

hypothalamus: 77 nTPM
medulla oblongata: 76 nTPM
choroid plexus: 71 nTPM
pons: 64 nTPM
cerebral cortex: 63 nTPM
thalamus: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.76
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protease binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FLOT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLOT2 as an antibody target. Whether an autoantibody or antibody against FLOT2 could matter depends on whether native FLOT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLOT2 is annotated at the cell surface, where native FLOT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FLOT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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