Seroatlas · Human Serome Atlas

ARL6IP6

ADP-ribosylation factor-like protein 6-interacting protein 6

Also known as: AR6P6_HUMAN, MGC33864

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6S5
Gene: ARL6IP6
Ensembl: ENSG00000177917
Chromosome: 2
Canonical length: 226 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q8N6S5|ARL6IP6
     1  MSFAESGWRS ALRRRGPGTP GPVARPSYSS FTQGDSWGEG EVDEEEGCDQ VARDLRAEFS
    61  AGAWSEPRKR SVLPPDGNGS PVLPDKRNGI FPAAAGSRAQ PRRWPVQVLS ILCSLLFAIL
   121  LAFLLAIAYL IVKELHAENL KNEDDVDTGL LGFWTLLIIS LTAGFSCCSF SWTVTYFDSF
   181  EPGMFPPTPL SPARFKKLTG HSFHMGYSMA ILNGIVAALT VAWCLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL6IP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 54 nTPM
placenta: 27 nTPM
skin: 24 nTPM
bone marrow: 23 nTPM
thymus: 20 nTPM
tonsil: 18 nTPM

Single-cell type

migrating cytotrophoblasts: 234 nCPM
cytotrophoblasts: 220 nCPM
extravillous trophoblasts: 183 nCPM
neutrophil progenitors: 158 nCPM
syncytiotrophoblasts: 141 nCPM
sertoli cells: 117 nCPM

Immune cell

basophil: 430 nTPM
eosinophil: 302 nTPM
plasmacytoid DC: 44 nTPM
neutrophil: 43 nTPM
T-reg: 39 nTPM
memory B-cell: 35 nTPM

Brain region

white matter: 16 nTPM
pons: 15 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 14 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0.02
gnomAD missense Z: -1.77
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nuclear inner membrane

Protein domainsUniProt · Pfam · InterPro

ADP-ribosylation factor-like protein 6-interacting protein 6
Haemopoietic lineage transmembrane helix

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL6IP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL6IP6 as an antibody target. Whether an autoantibody or antibody against ARL6IP6 could matter depends on whether native ARL6IP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL6IP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL6IP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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