Seroatlas · Human Serome Atlas

SIVA1

Apoptosis regulatory protein Siva

Also known as: CD27BP, SIVA, SIVA_HUMAN, Siva-1, Siva-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15304
Gene: SIVA1
Ensembl: ENSG00000184990
Chromosome: 14
Canonical length: 175 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>O15304|SIVA1
     1  MPKRSCPFAD VAPLQLKVRV SQRELSRGVC AERYSQEVFE KTKRLLFLGA QAYLDHVWDE
    61  GCAVVHLPES PKPGPTGAPR AARGQMLIGP DGRLIRSLGQ ASEADPSGVA SIACSSCVRA
   121  VDGKAVCGQC ERALCGQCVR TCWGCGSVAC TLCGLVDCSD MYEKVLCTSC AMFET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIVA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 178 nTPM
skeletal muscle: 172 nTPM
liver: 162 nTPM
colon: 109 nTPM
heart muscle: 106 nTPM
testis: 106 nTPM

Single-cell type

late primary spermatocytes: 451 nCPM
early primary spermatocytes: 420 nCPM
extravillous trophoblasts: 386 nCPM
esophageal basal cells: 369 nCPM
migrating cytotrophoblasts: 368 nCPM
cytotrophoblasts: 353 nCPM

Immune cell

plasmacytoid DC: 504 nTPM
eosinophil: 256 nTPM
basophil: 212 nTPM
memory B-cell: 206 nTPM
naive B-cell: 196 nTPM
T-reg: 196 nTPM

Brain region

choroid plexus: 40 nTPM
thalamus: 36 nTPM
medulla oblongata: 31 nTPM
white matter: 30 nTPM
spinal cord: 30 nTPM
hypothalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.03
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Siva
Cd27 binding protein (Siva)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIVA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIVA1 as an antibody target. Whether an autoantibody or antibody against SIVA1 could matter depends on whether native SIVA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIVA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIVA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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