PXMP2
Peroxisomal membrane protein 2
Also known as: MPV17L3, PMP22, PXMP2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NR77
- Gene
- PXMP2
- Ensembl
- ENSG00000176894
- Chromosome
- 12
- Canonical length
- 195 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
OverviewNCBI Gene
Located in peroxisomal membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
195 residues, UniProt reviewed canonical sequence.
>Q9NR77|PXMP2
1 MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF LAQMIEKKRK
61 KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP EVPLAGLRRL LLDRLVFAPA
121 FLMLFFLIMN FLEGKDASAF AAKMRGGFWP ALRMNWRVWT PLQFININYV PLKFRVLFAN
181 LAALFWYAYL ASLGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PXMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 295 nTPM
Expression across tissuesHPA
Tissue
- liver: 295 nTPM
- stomach: 90 nTPM
- kidney: 60 nTPM
- heart muscle: 58 nTPM
- choroid plexus: 53 nTPM
- small intestine: 52 nTPM
Single-cell type
- parietal cells: 131 nCPM
- hepatocytes: 112 nCPM
- gastric chief cells: 40 nCPM
- bergmann glia: 21 nCPM
- cholangiocytes: 18 nCPM
- colonocytes: 15 nCPM
Immune cell
- plasmacytoid DC: 6.4 nTPM
- T-reg: 3.2 nTPM
- eosinophil: 3 nTPM
- naive B-cell: 2.7 nTPM
- memory B-cell: 2.5 nTPM
- memory CD8 T-cell: 2.4 nTPM
Brain region
- choroid plexus: 51 nTPM
- hippocampal formation: 31 nTPM
- cerebral cortex: 24 nTPM
- thalamus: 24 nTPM
- cerebellum: 22 nTPM
- medulla oblongata: 22 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.27
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.5
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PXMP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PXMP2 as an antibody target. Whether an autoantibody or antibody against PXMP2 could matter depends on whether native PXMP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PXMP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PXMP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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