Seroatlas · Human Serome Atlas

SHLD2

Shieldin complex subunit 2

Also known as: bA163M19.1, FAM35A, FAM35A1, MGC5560, RINN2, SHLD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86V20
Gene
SHLD2
Ensembl
ENSG00000122376
Chromosome
10
Canonical length
835 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Actin filaments

OverviewNCBI Gene

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in actin cytoskeleton; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

835 residues, UniProt reviewed canonical sequence.

>Q86V20|SHLD2
     1  MSGGSQVHIF WGAPIAPLKI TVSEDTASLM SVADPWKKIQ LLYSQHSLYL KDEKQHKNLE
    61  NYKVPESIGS PDLSGHFLAN CMNRHVHVKD DFVRSVSETQ NIESQKIHSS RLSDITSSNM
   121  QICGFKSTVP HFTEEEKYQK LLSENKIRDE QPKHQPDICG KNFNTNLFQL GHKCAAVLDL
   181  VCSTEKINIG PEVVQRECVP TEYHEIQNQC LGLFSSNAVD KSRSEAAVRK VSDLKISTDT
   241  EFLSIITSSQ VAFLAQKKDK RRSPVNKGNV NMETEPKASY GEIRIPEENS IQLDGFTEAY
   301  ESGQNQAYSL ELFSPVCPKT ENSRIHINSD KGLEEHTGSQ ELFSSEDELP PNEIRIELCS
   361  SGILCSQLNT FHKSAIKRSC TSEDKVGQSE ALSRVLQVAK KMKLISNGGD SAVEMDRRNV
   421  SEFKSIKKTS LIKNCDSKSQ KYNCLVMVLS PCHVKEINIK FGPNSGSKVP LATVTVIDQS
   481  ETKKKVFLWR TAAFWAFTVF LGDIILLTDV VIHEDQWIGE TVLQSTFSSQ LLNLGSYSSI
   541  QPEEYSSVVS EVVLQDLLAY VSSKHSYLRD LPPRQPQRVN SIDFVELEHL QPDVLVHAVL
   601  RVVDFTILTE AVYSYRGQKQ KKVMLTVEQA QDQHYALVLW GPGAAWYPQL QRKKGVVLIK
   661  AQISELAFPI TASQKIALNA HSSLKSIFSS LPNIVYTGCA KCGLELETDE NRIYKQCFSC
   721  LPFTMKKIYY RPALMTAIDG RHDVCIRVES KLIEKILLNI SADCLNRVIV PSSEITYGMV
   781  VADLFHSLLA VSAEPCVLKI QSLFVLDENS YPLQQDFSLL DFYPDIVKHG ANARL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHLD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • liver: 35 nTPM
  • kidney: 30 nTPM
  • small intestine: 23 nTPM
  • thyroid gland: 22 nTPM
  • duodenum: 21 nTPM
  • adrenal gland: 19 nTPM

Single-cell type

  • proximal tubule cells: 243 nCPM
  • distal convoluted tubule cells: 219 nCPM
  • loop of henle epithelial cells: 201 nCPM
  • renal collecting duct intercalated cells: 196 nCPM
  • choroid plexus epithelial cells: 178 nCPM
  • somatotrophs: 177 nCPM

Immune cell

  • MAIT T-cell: 14 nTPM
  • NK-cell: 13 nTPM
  • intermediate monocyte: 12 nTPM
  • myeloid DC: 11 nTPM
  • T-reg: 10 nTPM
  • naive CD8 T-cell: 10 nTPM

Brain region

  • medulla oblongata: 72 nTPM
  • midbrain: 36 nTPM
  • amygdala: 34 nTPM
  • thalamus: 34 nTPM
  • choroid plexus: 33 nTPM
  • cerebral cortex: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Shieldin complex subunit 2
  • Shieldin complex subunit 2, C-terminal domain
  • Shieldin complex subunit 2, first OB fold domain
  • Shieldin complex subunit 2, second OB fold domain
  • Shieldin complex subunit 2, C-terminal
  • Shieldin complex subunit 2, first OB fold domain
  • Shieldin complex subunit 2, second OB fold domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHLD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHLD2 as an antibody target. Whether an autoantibody or antibody against SHLD2 could matter depends on whether native SHLD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHLD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHLD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHLD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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