Seroatlas · Human Serome Atlas

SHLD1

Shieldin complex subunit 1

Also known as: C20orf196, FLJ25067, RINN3, SHLD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYI0
Gene: SHLD1
Ensembl: ENSG00000171984
Chromosome: 20
Canonical length: 205 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus,Vesicles

OverviewNCBI Gene

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q8IYI0|SHLD1
     1  MAARDATSGS LSEESSALDL PSACDIRDYV LQGPSQEANS EAFSSLEFHS FPYSSDVDPD
    61  TSNLNIEQNN SWTAENFWLD PAVKGQSEKE EDDGLRKSLD RFYEMFGHPQ PGSANSLSAS
   121  VCKCLSQKIT QLRGQESQKY ALRSFQMARV IFNRDGCSVL QRHSRDTHFY PLEEGSTSLD
   181  DEKPNPGLSK DITHFLLQQN VMKDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHLD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
lymph node: 14 nTPM
thymus: 12 nTPM
tonsil: 11 nTPM
skeletal muscle: 9.3 nTPM
duodenum: 8.5 nTPM

Single-cell type

neutrophil progenitors: 113 nCPM
lacrimal acinar cells: 97 nCPM
adrenal cortex cells: 94 nCPM
enterocytes: 91 nCPM
microglia: 90 nCPM
myonuclei: 85 nCPM

Immune cell

naive B-cell: 33 nTPM
T-reg: 32 nTPM
memory B-cell: 28 nTPM
memory CD4 T-cell: 25 nTPM
NK-cell: 24 nTPM
naive CD4 T-cell: 23 nTPM

Brain region

cerebellum: 14 nTPM
pons: 12 nTPM
white matter: 12 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 11 nTPM
basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0.17
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Shieldin complex subunit 1
Shieldin complex subunit 1, C-terminal domain
Shieldin complex subunit 1, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHLD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHLD1 as an antibody target. Whether an autoantibody or antibody against SHLD1 could matter depends on whether native SHLD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHLD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHLD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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