Seroatlas · Human Serome Atlas

SFXN1

Sideroflexin-1

Also known as: FLJ12876, SFXN1_HUMAN, SLC56A1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9B4
Gene: SFXN1
Ensembl: ENSG00000164466
Chromosome: 5
Canonical length: 322 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables L-alanine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in L-alanine transport; L-serine transport; and serine import into mitochondrion. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q9H9B4|SFXN1
     1  MSGELPPNIN IKEPRWDQST FIGRANHFFT VTDPRNILLT NEQLESARKI VHDYRQGIVP
    61  PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN MTITGCMMTF YRTTPAVLFW
   121  QWINQSFNAV VNYTNRSGDA PLTVNELGTA YVSATTGAVA TALGLNALTK HVSPLIGRFV
   181  PFAAVAAANC INIPLMRQRE LKVGIPVTDE NGNRLGESAN AAKQAITQVV VSRILMAAPG
   241  MAIPPFIMNT LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA
   301  ELQAKIQESH PELRRVYFNK GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFXN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

liver: 93 nTPM
kidney: 39 nTPM
cerebral cortex: 27 nTPM
colon: 26 nTPM
tonsil: 25 nTPM
lymph node: 25 nTPM

Single-cell type

neutrophil progenitors: 246 nCPM
hepatocytes: 157 nCPM
choroid plexus epithelial cells: 134 nCPM
lactotrophs: 133 nCPM
leydig cells: 115 nCPM
gonadotrophs: 115 nCPM

Immune cell

basophil: 100 nTPM
memory CD4 T-cell: 36 nTPM
T-reg: 32 nTPM
naive CD8 T-cell: 29 nTPM
memory CD8 T-cell: 29 nTPM
naive CD4 T-cell: 28 nTPM

Brain region

cerebral cortex: 46 nTPM
hypothalamus: 43 nTPM
choroid plexus: 42 nTPM
cerebellum: 41 nTPM
basal ganglia: 41 nTPM
white matter: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFXN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFXN1 as an antibody target. Whether an autoantibody or antibody against SFXN1 could matter depends on whether native SFXN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFXN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFXN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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