TMEM14B
Transmembrane protein 14B
Also known as: MGC1223, TM14B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NUH8
- Gene
- TMEM14B
- Ensembl
- ENSG00000137210
- Chromosome
- 6
- Canonical length
- 114 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
Enables identical protein binding activity. Involved in cerebral cortex development; neural precursor cell proliferation; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>Q9NUH8|TMEM14B
1 MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG LGAYQLYQDP
61 RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL MAAKVGVRML MTSDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM14B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 176 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 176 nTPM
- retina: 140 nTPM
- skeletal muscle: 137 nTPM
- tongue: 132 nTPM
- heart muscle: 124 nTPM
- thyroid gland: 120 nTPM
Single-cell type
- erythrocyte progenitors: 162 nCPM
- fallopian tube ciliated cells: 105 nCPM
- respiratory ciliated cells: 89 nCPM
- retinal pigment epithelial cells: 68 nCPM
- fallopian secretory cells: 67 nCPM
- oocytes: 65 nCPM
Immune cell
- basophil: 179 nTPM
- plasmacytoid DC: 169 nTPM
- eosinophil: 162 nTPM
- total PBMC: 155 nTPM
- T-reg: 141 nTPM
- myeloid DC: 137 nTPM
Brain region
- choroid plexus: 76 nTPM
- cerebellum: 45 nTPM
- white matter: 45 nTPM
- medulla oblongata: 41 nTPM
- spinal cord: 40 nTPM
- hypothalamus: 40 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.5
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cerebral cortex development
- heme biosynthetic process
- neural precursor cell proliferation
- regulation of G1/S transition of mitotic cell cycle
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMEM14B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM14B as an antibody target. Whether an autoantibody or antibody against TMEM14B could matter depends on whether native TMEM14B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM14B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM14B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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