Seroatlas · Human Serome Atlas

SFR1

Swi5-dependent recombination DNA repair protein 1 homolog

Also known as: bA373N18.1, C10orf78, FLJ41960, MEI5, MEIR5, SFR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86XK3
Gene
SFR1
Ensembl
ENSG00000156384
Chromosome
10
Canonical length
245 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli rim,Centrosome

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of DNA-templated transcription. Located in centrosome; nucleolus; and nucleoplasm. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q86XK3|SFR1
     1  MAEGEKNQDF TFKMESPSDS AVVLPSTPQA SANPSSPYTN SSRKQPMSAT LRERLRKTRF
    61  SFNSSYNVVK RLKVESEEND QTFSEKPASS TEENCLEFQE SFKHIDSEFE ENTNLKNTLK
   121  NLNVCESQSL DSGSCSALQN EFVSEKLPKQ RLNAEKAKLV KQVQEKEDLL RRLKLVKMYR
   181  SKNDLSQLQL LIKKWRSCSQ LLLYELQSAV SEENKKLSLT QLIDHYGLDD KLLHYNRSEE
   241  EFIDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • thymus: 11 nTPM
  • spinal cord: 10 nTPM
  • bone marrow: 9.4 nTPM
  • lymph node: 8.4 nTPM
  • ovary: 8.2 nTPM

Single-cell type

  • early primary spermatocytes: 252 nCPM
  • differentiating spermatogonia: 56 nCPM
  • late primary spermatocytes: 55 nCPM
  • oocytes: 37 nCPM
  • schwann cells: 25 nCPM
  • monocyte progenitors: 25 nCPM

Immune cell

  • basophil: 24 nTPM
  • naive CD4 T-cell: 22 nTPM
  • naive B-cell: 19 nTPM
  • naive CD8 T-cell: 18 nTPM
  • classical monocyte: 17 nTPM
  • memory B-cell: 17 nTPM

Brain region

  • white matter: 19 nTPM
  • basal ganglia: 13 nTPM
  • medulla oblongata: 13 nTPM
  • thalamus: 11 nTPM
  • cerebellum: 11 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
-0.42
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • SFR1/Mei5 family
  • Swi5-dependent recombination DNA repair protein 1 homolog
  • Double-strand recombination repair protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFR1 as an antibody target. Whether an autoantibody or antibody against SFR1 could matter depends on whether native SFR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SFR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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