Seroatlas · Human Serome Atlas

YJU2

Splicing factor YJU2

Also known as: CCDC94, FLJ10374, YJU2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BW85
Gene: YJU2
Ensembl: ENSG00000105248
Chromosome: 19
Canonical length: 323 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to be involved in RNA splicing and negative regulation of DNA damage response, signal transduction by p53 class mediator. Part of U2-type catalytic step 1 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q9BW85|YJU2
     1  MSERKVLNKY YPPDFDPSKI PKLKLPKDRQ YVVRLMAPFN MRCKTCGEYI YKGKKFNARK
    61  ETVQNEVYLG LPIFRFYIKC TRCLAEITFK TDPENTDYTM EHGATRNFQA EKLLEEEEKR
   121  VQKEREDEEL NNPMKVLENR TKDSKLEMEV LENLQELKDL NQRQAHVDFE AMLRQHRLSE
   181  EERRRQQQEE DEQETAALLE EARKRRLLED SDSEDEAAPS PLQPALRPNP TAILDEAPKP
   241  KRKVEVWEQS VGSLGSRPPL SRLVVVKKAK ADPDCSNGQP QAAPTPGAPQ NRKEANPTPL
   301  TPGASSLSQL GAYLDSDDSN GSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YJU2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 42 nTPM
cerebellum: 24 nTPM
pancreas: 23 nTPM
skin: 23 nTPM
skeletal muscle: 22 nTPM
spinal cord: 20 nTPM

Single-cell type

syncytiotrophoblasts: 61 nCPM
esophageal suprabasal cells: 52 nCPM
esophageal apical cells: 52 nCPM
esophageal basal cells: 50 nCPM
migrating cytotrophoblasts: 42 nCPM
oocytes: 41 nCPM

Immune cell

T-reg: 34 nTPM
naive B-cell: 33 nTPM
eosinophil: 31 nTPM
memory B-cell: 31 nTPM
naive CD4 T-cell: 29 nTPM
gdT-cell: 26 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 25 nTPM
basal ganglia: 22 nTPM
cerebellum: 22 nTPM
pons: 21 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
DepMap mean gene effect: -1.53
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YJU2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRP16
SETMAR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YJU2 as an antibody target. Whether an autoantibody or antibody against YJU2 could matter depends on whether native YJU2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YJU2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YJU2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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