Seroatlas · Human Serome Atlas

SELENOF

Selenoprotein F

Also known as: 15-Sep, SEP15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60613
Gene: SELENOF
Ensembl: ENSG00000183291
Chromosome: 1
Canonical length: 165 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>O60613|SELENOF
     1  MVAMAAGPSG CLVPAFGLRL LLATVLQAVS AFGAEFSSEA CRELGFSSNL LCSSCDLLGQ
    61  FNLLQLDPDC RGCCQEEAQF ETKKLYAGAI LEVCGUKLGR FPQVQAFVRS DKPKLFRGLQ
   121  IKYVRGSDPV LKLLDDNGNI AEELSILKWN TDSVEEFLSE KLERI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 219 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 219 nTPM
epididymis: 200 nTPM
liver: 163 nTPM
kidney: 149 nTPM
cervix: 147 nTPM
placenta: 146 nTPM

Single-cell type

extravillous trophoblasts: 477 nCPM
syncytiotrophoblasts: 403 nCPM
decidual stromal cells: 388 nCPM
migrating cytotrophoblasts: 306 nCPM
cytotrophoblasts: 295 nCPM
hofbauer cells: 263 nCPM

Immune cell

naive B-cell: 195 nTPM
total PBMC: 171 nTPM
basophil: 171 nTPM
plasmacytoid DC: 167 nTPM
memory B-cell: 162 nTPM
non-classical monocyte: 133 nTPM

Brain region

choroid plexus: 90 nTPM
white matter: 79 nTPM
spinal cord: 66 nTPM
hypothalamus: 61 nTPM
medulla oblongata: 60 nTPM
cerebellum: 54 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

endoplasmic reticulum lumen

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SELENOF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELENOF as an antibody target. Whether an autoantibody or antibody against SELENOF could matter depends on whether native SELENOF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELENOF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SELENOF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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