Seroatlas · Human Serome Atlas

SCN3B

Sodium channel regulatory subunit beta-3

Also known as: HSA243396, SCN3B_HUMAN, SCNB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NY72
Gene
SCN3B
Ensembl
ENSG00000166257
Chromosome
11
Canonical length
215 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q9NY72|SCN3B
     1  MPAFNRLFPL ASLVLIYWVS VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV
    61  EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC
   121  NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLLIEMIYC
   181  YRKVSKAEEA AQENASDYLA IPSENKENSA VPVEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCN3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 73 nTPM
  • hippocampal formation: 46 nTPM
  • amygdala: 27 nTPM
  • pituitary gland: 27 nTPM
  • hypothalamus: 23 nTPM
  • basal ganglia: 22 nTPM

Single-cell type

  • lactotrophs: 178 nCPM
  • lymphatic endothelial cells: 175 nCPM
  • retinal amacrine cells: 146 nCPM
  • thyrotrophs: 139 nCPM
  • brain excitatory neurons: 101 nCPM
  • other brain neurons: 97 nCPM

Immune cell

  • neutrophil: 0.4 nTPM
  • basophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM

Brain region

  • hippocampal formation: 167 nTPM
  • cerebral cortex: 165 nTPM
  • basal ganglia: 131 nTPM
  • white matter: 88 nTPM
  • amygdala: 80 nTPM
  • midbrain: 63 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCN3B.

Disease | AllUniProt

Conditions SCN3B is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 265 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Atrial fibrillation, familial, 16

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.05
gnomAD missense Z
0.79
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCN3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCN3B as an antibody target. Whether an autoantibody or antibody against SCN3B could matter depends on whether native SCN3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCN3B is annotated at the cell surface, where native SCN3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCN3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCN3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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