Seroatlas · Human Serome Atlas

SFXN3

Sideroflexin-3

Also known as: SFX3, SFXN3_HUMAN, SLC56A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWM7
Gene: SFXN3
Ensembl: ENSG00000107819
Chromosome: 10
Canonical length: 321 aa
Protein class: Metabolic proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables L-serine transmembrane transporter activity. Involved in serine import into mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q9BWM7|SFXN3
     1  MGELPLDINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG AQLEASRNIV QNYRAGVVTP
    61  GITEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM TITGCMLTFY RKTPTVVFWQ
   121  WVNQSFNAIV NYSNRSGDTP ITVRQLGTAY VSATTGAVAT ALGLKSLTKH LPPLVGRFVP
   181  FAAVAAANCI NIPLMRQREL QVGIPVADEA GQRLGYSVTA AKQGIFQVVI SRICMAIPAM
   241  AIPPLIMDTL EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQKS SIHISNLEPE
   301  LRAQIHEQNP SVEVVYYNKG L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFXN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 47 nTPM
small intestine: 41 nTPM
blood vessel: 40 nTPM
duodenum: 34 nTPM
smooth muscle: 26 nTPM
retina: 24 nTPM

Single-cell type

late spermatids: 275 nCPM
enterocytes: 120 nCPM
extravillous trophoblasts: 64 nCPM
early spermatids: 60 nCPM
respiratory ciliated cells: 56 nCPM
hofbauer cells: 54 nCPM

Immune cell

myeloid DC: 22 nTPM
classical monocyte: 21 nTPM
intermediate monocyte: 15 nTPM
total PBMC: 14 nTPM
gdT-cell: 12 nTPM
basophil: 11 nTPM

Brain region

cerebellum: 47 nTPM
cerebral cortex: 45 nTPM
white matter: 45 nTPM
pons: 44 nTPM
hippocampal formation: 41 nTPM
basal ganglia: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFXN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SCN3B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFXN3 as an antibody target. Whether an autoantibody or antibody against SFXN3 could matter depends on whether native SFXN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFXN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFXN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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