Seroatlas · Human Serome Atlas

ERG28

Ergosterol biosynthetic protein 28 homolog

Also known as: C14orf1, ERG28_HUMAN, NET51

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKR5
Gene: ERG28
Ensembl: ENSG00000133935
Chromosome: 14
Canonical length: 140 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in sterol biosynthetic process. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q9UKR5|ERG28
     1  MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS
    61  SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG
   121  MLVGLRYLEV EPVSRQKKRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERG28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

liver: 66 nTPM
testis: 48 nTPM
epididymis: 38 nTPM
esophagus: 38 nTPM
adrenal gland: 31 nTPM
spinal cord: 30 nTPM

Single-cell type

late primary spermatocytes: 348 nCPM
esophageal apical cells: 313 nCPM
esophageal suprabasal cells: 276 nCPM
epididymal principal cells: 221 nCPM
granulosa cells: 204 nCPM
alveolar cells type 2: 203 nCPM

Immune cell

memory CD4 T-cell: 43 nTPM
T-reg: 43 nTPM
memory CD8 T-cell: 42 nTPM
gdT-cell: 40 nTPM
MAIT T-cell: 40 nTPM
memory B-cell: 40 nTPM

Brain region

white matter: 27 nTPM
medulla oblongata: 25 nTPM
thalamus: 24 nTPM
pons: 24 nTPM
spinal cord: 23 nTPM
midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.24
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sterol biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Erg28
Erg28 like protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERG28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERG28 as an antibody target. Whether an autoantibody or antibody against ERG28 could matter depends on whether native ERG28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERG28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERG28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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