ZNF330
Zinc finger protein 330
Also known as: HSA6591, NOA36, ZN330_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y3S2
- Gene
- ZNF330
- Ensembl
- ENSG00000109445
- Chromosome
- 4
- Canonical length
- 320 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Primary cilium,Basal body,Cytosol
OverviewNCBI Gene
Predicted to enable metal ion binding activity. Located in several cellular components, including ciliary basal body; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
320 residues, UniProt reviewed canonical sequence.
>Q9Y3S2|ZNF330
1 MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS
61 VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC
121 ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR
181 LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG
241 GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT
301 NLNLGRTYAS GYAHYEEQENLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF330 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 94 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 94 nTPM
- skeletal muscle: 63 nTPM
- liver: 48 nTPM
- salivary gland: 45 nTPM
- tongue: 41 nTPM
- thyroid gland: 35 nTPM
Single-cell type
- early spermatids: 241 nCPM
- decidual stromal cells: 161 nCPM
- late primary spermatocytes: 130 nCPM
- hofbauer cells: 123 nCPM
- hepatocytes: 87 nCPM
- melanocytes: 81 nCPM
Immune cell
- myeloid DC: 29 nTPM
- classical monocyte: 28 nTPM
- T-reg: 26 nTPM
- intermediate monocyte: 23 nTPM
- MAIT T-cell: 22 nTPM
- memory B-cell: 22 nTPM
Brain region
- choroid plexus: 18 nTPM
- white matter: 16 nTPM
- cerebellum: 16 nTPM
- medulla oblongata: 14 nTPM
- spinal cord: 13 nTPM
- thalamus: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.55
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger protein NOA36
- NOA36 protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF330 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF330 as an antibody target. Whether an autoantibody or antibody against ZNF330 could matter depends on whether native ZNF330 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF330 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF330 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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