Seroatlas · Human Serome Atlas

RTF1

RNA polymerase-associated protein RTF1 homolog

Also known as: KIAA0252, RTF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92541
Gene
RTF1
Ensembl
ENSG00000137815
Chromosome
15
Canonical length
710 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

710 residues, UniProt reviewed canonical sequence.

>Q92541|RTF1
     1  MRGRLCVGRA AAAAAAVAVP LAGGQEGSPG GGRRGSRGTT MVKKRKGRVV IDSDTEDSGS
    61  DENLDQELLS LAKRKRSDSE EKEPPVSQPA ASSDSETSDS DDEWTFGSNK NKKKGKARKI
   121  EKKGTMKKQA NKTASSGSSD KDSSAESSAP EEGEVSDSDS NSSSSSSDSD SSSEDEEFHD
   181  GYGEDLMGDE EDRARLEQMT EKEREQELFN RIEKREVLKR RFEIKKKLKT AKKKEKKEKK
   241  KKQEEEQEKK KLTQIQESQV TSHNKERRSK RDEKLDKKSQ AMEELKAERE KRKNRTAELL
   301  AKKQPLKTSE VYSDDEEEEE DDKSSEKSDR SSRTSSSDEE EEKEEIPPKS QPVSLPEELN
   361  RVRLSRHKLE RWCHMPFFAK TVTGCFVRIG IGNHNSKPVY RVAEITGVVE TAKVYQLGGT
   421  RTNKGLQLRH GNDQRVFRLE FVSNQEFTES EFMKWKEAMF SAGMQLPTLD EINKKELSIK
   481  EALNYKFNDQ DIEEIVKEKE RFRKAPPNYA MKKTQLLKEK AMAEDLGDQD KAKQIQDQLN
   541  ELEERAEALD RQRTKNISAI SYINQRNREW NIVESEKALV AESHNMKNQQ MDPFTRRQCK
   601  PTIVSNSRDP AVQAAILAQL NAKYGSGVLP DAPKEMSKGQ GKDKDLNSKS ASDLSEDLFK
   661  VHDFDVKIDL QVPSSESKAL AITSKAPPAK DGAPRRSLNL EDYKKRRGLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 46 nTPM
  • bone marrow: 43 nTPM
  • parathyroid gland: 35 nTPM
  • tongue: 33 nTPM
  • cerebellum: 30 nTPM
  • testis: 28 nTPM

Single-cell type

  • late primary spermatocytes: 485 nCPM
  • late spermatids: 464 nCPM
  • early spermatids: 303 nCPM
  • syncytiotrophoblasts: 299 nCPM
  • esophageal apical cells: 239 nCPM
  • hepatocytes: 228 nCPM

Immune cell

  • neutrophil: 8.5 nTPM
  • eosinophil: 6.9 nTPM
  • memory B-cell: 6.9 nTPM
  • NK-cell: 6.3 nTPM
  • plasmacytoid DC: 5.5 nTPM
  • basophil: 5.3 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • cerebellum: 37 nTPM
  • basal ganglia: 35 nTPM
  • hippocampal formation: 35 nTPM
  • amygdala: 33 nTPM
  • white matter: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.12
gnomAD pLI
1
gnomAD missense Z
4.59
DepMap mean gene effect
-0.96
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Plus-3 domain
  • Plus3-like superfamily
  • Plus-3 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTF1 as an antibody target. Whether an autoantibody or antibody against RTF1 could matter depends on whether native RTF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RTF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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