Seroatlas · Human Serome Atlas

RPP21

Ribonuclease P protein subunit p21

Also known as: C6orf135, Em:AB014085.3, FLJ22638, RPP21_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H633
Gene: RPP21
Ensembl: ENSG00000241370
Chromosome: 6
Canonical length: 154 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q9H633|RPP21
     1  MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCY TERTIAKRLV LRRDPSVKRT
    61  LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR FLNDPGHLLW GDRPEAQLGS
   121  QADSKPLQPL PNTAHSISDR LPEEKMQTQG SSNQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPP21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

colon: 70 nTPM
esophagus: 60 nTPM
basal ganglia: 60 nTPM
pancreas: 60 nTPM
endometrium: 59 nTPM
urinary bladder: 55 nTPM

Single-cell type

gastric chief cells: 39 nCPM
oocytes: 37 nCPM
parietal cells: 30 nCPM
paneth cells: 27 nCPM
other brain neurons: 24 nCPM
oligodendrocytes: 23 nCPM

Immune cell

memory B-cell: 87 nTPM
naive B-cell: 86 nTPM
T-reg: 70 nTPM
basophil: 60 nTPM
non-classical monocyte: 54 nTPM
naive CD4 T-cell: 52 nTPM

Brain region

hypothalamus: 6.5 nTPM
white matter: 5.9 nTPM
cerebral cortex: 5.1 nTPM
medulla oblongata: 5 nTPM
pons: 4.4 nTPM
spinal cord: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -1.29
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribonuclease P subunit, Rpr2/Snm1/Rpp21
RNAse P Rpr2/Rpp21/SNM1 subunit domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPP21 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RPP40

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPP21 as an antibody target. Whether an autoantibody or antibody against RPP21 could matter depends on whether native RPP21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPP21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPP21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...