Seroatlas · Human Serome Atlas

RMDN2

Regulator of microtubule dynamics protein 2

Also known as: FAM82A, FAM82A1, FLJ32954, RMD2, RMD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LZ7
Gene: RMDN2
Ensembl: ENSG00000115841
Chromosome: 2
Canonical length: 410 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables microtubule binding activity. Located in Golgi apparatus; cytosol; and spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q96LZ7|RMDN2
     1  MPYSTNKELI LGIMVGTAGI SLLLLWYHKV RKPGIAMKLP EFLSLGNTFN SITLQDEIHD
    61  DQGTTVIFQE RQLQILEKLN ELLTNMEELK EEIRFLKEAI PKLEEYIQDE LGGKITVHKI
   121  SPQHRARKRR LPTIQSSATS NSSEEAESEG GYITANTDTE EQSFPVPKAF NTRVEELNLD
   181  VLLQKVDHLR MSESGKSESF ELLRDHKEKF RDEIEFMWRF ARAYGDMYEL STNTQEKKHY
   241  ANIGKTLSER AINRAPMNGH CHLWYAVLCG YVSEFEGLQN KINYGHLFKE HLDIAIKLLP
   301  EEPFLYYLKG RYCYTVSKLS WIEKKMAATL FGKIPSSTVQ EALHNFLKAE ELCPGYSNPN
   361  YMYLAKCYTD LEENQNALKF CNLALLLPTV TKEDKEAQKE MQKIMTSLKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RMDN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 40 nTPM
liver: 27 nTPM
testis: 20 nTPM
spleen: 19 nTPM
small intestine: 13 nTPM
seminal vesicle: 12 nTPM

Single-cell type

adrenal cortex cells: 327 nCPM
early spermatids: 255 nCPM
late spermatids: 240 nCPM
late primary spermatocytes: 212 nCPM
myonuclei: 90 nCPM
enterocytes: 80 nCPM

Immune cell

intermediate monocyte: 4.6 nTPM
memory B-cell: 4.1 nTPM
NK-cell: 3.7 nTPM
non-classical monocyte: 3.5 nTPM
plasmacytoid DC: 3.4 nTPM
MAIT T-cell: 3.1 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 9.4 nTPM
hippocampal formation: 9.2 nTPM
white matter: 8.7 nTPM
amygdala: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -2.23
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RMDN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RMDN2 as an antibody target. Whether an autoantibody or antibody against RMDN2 could matter depends on whether native RMDN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RMDN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RMDN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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