Seroatlas · Human Serome Atlas

RCC1

Regulator of chromosome condensation

Also known as: CHC1, RCC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18754
Gene
RCC1
Ensembl
ENSG00000180198
Chromosome
1
Canonical length
421 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nuclear lumen. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>P18754|RCC1
     1  MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP
    61  ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK
   121  VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG
   181  NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV
   241  RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS
   301  GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV
   361  TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ
   421  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 56 nTPM
  • thymus: 41 nTPM
  • testis: 40 nTPM
  • tonsil: 36 nTPM
  • lymph node: 35 nTPM
  • appendix: 30 nTPM

Single-cell type

  • late spermatids: 1,379 nCPM
  • early spermatids: 231 nCPM
  • alveolar cells type 2: 171 nCPM
  • transitional alveolar cells: 106 nCPM
  • esophageal basal cells: 78 nCPM
  • migrating cytotrophoblasts: 75 nCPM

Immune cell

  • myeloid DC: 14 nTPM
  • MAIT T-cell: 9.2 nTPM
  • memory CD8 T-cell: 8.2 nTPM
  • intermediate monocyte: 7.8 nTPM
  • memory CD4 T-cell: 7.7 nTPM
  • plasmacytoid DC: 7.7 nTPM

Brain region

  • thalamus: 12 nTPM
  • cerebellum: 11 nTPM
  • medulla oblongata: 10 nTPM
  • pons: 10 nTPM
  • white matter: 10 nTPM
  • choroid plexus: 9.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RCC1.

Disease | AllUniProt

Conditions RCC1 is implicated in, by any mechanism.

  • Infection-induced acute-onset axonal neuropathy (IIAAN) MIM:621333

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 63 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • See cases
  • Infection-induced acute-onset axonal neuropathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.93
gnomAD missense Z
1.68
DepMap mean gene effect
-1.54
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCC1 as an antibody target. Whether an autoantibody or antibody against RCC1 could matter depends on whether native RCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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