Seroatlas · Human Serome Atlas

RANBP1

Ran-specific GTPase-activating protein

Also known as: HTF9A, RANG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43487
Gene
RANBP1
Ensembl
ENSG00000099901
Chromosome
22
Canonical length
201 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P43487|RANBP1
     1  MAAAKDTHED HDTSTENTDE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK MRAKLFRFAS
    61  ENDLPEWKER GTGDVKLLKH KEKGAIRLLM RRDKTLKICA NHYITPMMEL KPNAGSDRAW
   121  VWNTHADFAD ECPKPELLAI RFLNAENAQK FKTKFEECRK EIEEREKKAG SGKNDHAEKV
   181  AEKLEALSVK EETKEDAEEK Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • testis: 113 nTPM
  • bone marrow: 111 nTPM
  • thymus: 97 nTPM
  • esophagus: 91 nTPM
  • lymph node: 88 nTPM
  • liver: 83 nTPM

Single-cell type

  • extravillous trophoblasts: 814 nCPM
  • late primary spermatocytes: 776 nCPM
  • migrating cytotrophoblasts: 719 nCPM
  • esophageal basal cells: 630 nCPM
  • differentiating spermatogonia: 595 nCPM
  • gastric progenitor cells: 505 nCPM

Immune cell

  • memory B-cell: 124 nTPM
  • naive B-cell: 120 nTPM
  • T-reg: 116 nTPM
  • myeloid DC: 112 nTPM
  • plasmacytoid DC: 104 nTPM
  • total PBMC: 103 nTPM

Brain region

  • cerebral cortex: 66 nTPM
  • white matter: 65 nTPM
  • pons: 61 nTPM
  • medulla oblongata: 61 nTPM
  • spinal cord: 60 nTPM
  • hypothalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.82
gnomAD missense Z
1.99
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANBP1 as an antibody target. Whether an autoantibody or antibody against RANBP1 could matter depends on whether native RANBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RANBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RANBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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